Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress

Sinsinwar, Simran; Vadivel, Vellingiri

doi:10.1007/s00253-020-10853-z

Cited by 56 publications

(29 citation statements)

References 91 publications

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“…Fathima et al and Sinsinwar et al described the membrane disruption antimicrobial activity of catechin isolated from different plants [ 63 , 64 ]. Catechin is a hydroxylated flavanol known for its potent free radical scavenger activity and antibacterial activity toward Gram-positive and Gram-negative bacteria [ 65 ].…”

Section: Bacterial Membranementioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.

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Section: Bacterial Membranementioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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“…Gallic acid, catechin, and vanillic acid are the major phenolic compounds found in cereal vinegars [17]. The antimicrobial potential of these compounds against various pathogens, such as E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter spp., Listeria spp., Mannheimia haemolytica, Pasteurella multocida, etc., has been demonstrated in several studies [74][75][76][77][78][79].…”

Section: Antimicrobial Propertiesmentioning

confidence: 74%

Health Promoting Properties of Cereal Vinegars

Kandylis

Bekatorou

Dimitrellou

et al. 2021

Foods

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Vinegar has been used for its health promoting properties since antiquity. Nowadays, these properties are investigated, scientifically documented, and highlighted. The health benefits of vinegar have been associated with the presence of a variety of bioactive components such as acetic acid and other organic acids, phenolic compounds, amino acids, carotenoids, phytosterols, vitamins, minerals, and alkaloids, etc. These components are known to induce responses in the human body, such as antioxidant, antidiabetic, antimicrobial, antitumor, antiobesity, antihypertensive, and anti-inflammatory effects. The diversity and levels of bioactive components in vinegars depend on the raw material and the production method used. Cereal vinegars, which are more common in the Asia-Pacific region, are usually made from rice, although other cereals, such as millet, sorghum, barley, malt, wheat, corn, rye, oats, bran and chaff, are also used. A variety of bioactive components, such as organic acids, polyphenols, amino acids, vitamins, minerals, alkaloids, melanoidins, butenolides, and specific compounds such as γ-oryzanol, tetramethylpyrazine, γ-aminobutyric acid, etc., have been associated with the health properties of cereal vinegars. In this work, the bioactive components and the related health effects of cereal vinegars are reviewed, and the most recent scientific literature is presented and discussed.

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“…Moreover, C has been well-characterized for its antibacterial activities and known for its ability to cause leakage of bacterial cellular contents along with increased intracellular reactive oxygen species production in both gram negatives and positives 71,72 . However, the biological targets of C have not been described.…”

Section: Discussionmentioning

confidence: 99%

Chromatographic Analyses, Virtual Screening and Pharmacokinetics of Yellow Malaysian Rambutan (Nephelium lappaceum L.) Fruit Epicarp Extracts Reveal Potential Antibacterial Compounds

Asghar¹,

Tan²,

Zahoor³

et al. 2020

Preprint

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The emergence and spread of antimicrobial resistance have been of serious concern on human health and the management of bacterial infectious diseases. Effective treatment of these diseases requires the development of novel therapeutics, preferably free of side effects. In this regard, natural products are frequently conceived to be potential alternative sources for novel antibacterial compounds. Herein, we have evaluated the antibacterial activity of the epicarp extracts of the Malaysian cultivar of yellow rambutan fruit (Nephelium lappaceum L.) against six pathogens namely, Bacillus subtilis, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae and Salmonella enterica. Among a series of solvent extracts, fractions of ethyl acetate and acetone have revealed significant activity towards all tested strains. Chemical profiling of these fractions, via HPLC, LC-MS and GC-MS, has generated a library of potential bioactive compounds. Downstream virtual screening, pharmacological prediction, and receptor-ligand molecular dynamics simulation have eventually unveiled novel potential antibacterial compounds, which can be extracted for medicinal use. To this end, we report novel mechanistic aspects of these compounds in competitively inhibiting the ATP-binding domain of the DnaK chaperone of P. aeruginosa and MRSA. Our work takes a step forward to discover antimicrobials capable of perforating the barrier of resistance posed by both the gram positives and the negatives.

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Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress

Cited by 56 publications

References 91 publications

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Health Promoting Properties of Cereal Vinegars

Chromatographic Analyses, Virtual Screening and Pharmacokinetics of Yellow Malaysian Rambutan (Nephelium lappaceum L.) Fruit Epicarp Extracts Reveal Potential Antibacterial Compounds

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