Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eye therapeutics

Shim, Whuisu; Kim, Chae Eun; Lee, Mihyun; Lee, Soo Hyun; Park, Joseph; Do, Minjae; Yang, Jong In; Lee, Haeshin

doi:10.1016/j.jconrel.2019.04.016

Cited by 37 publications

(17 citation statements)

References 43 publications

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“…Finally, it is also true that in vivo models are much more complex. For many of the compounds [72,73,76,77,79,[91][92][93] and extracts [46,87,88,[94][95][96][97] mentioned in the bibliography, the anti-inflammatory activity has also been proven in vivo. For EGCG [98] and Daidzin [73], the in vivo antioxidant effect has also been studied.…”

Section: Discussionmentioning

confidence: 99%

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

2021

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Oxidative- and inflammatory-related ocular surface diseases have high prevalence and are an emerging issue in ophthalmology. Olive pomace (OP) is the olive oil’s industry main by-product, and is potentially environmentally hazardous. Nevertheless, it contains phenolic compounds with important bioactivities, like oleuropein (OL) and hydroxytyrosol (HT). The antioxidant and anti-inflammatory effects of four OP extracts (CONV, OPT(1–3)), pure OL and HT, and mixtures thereof were screened on human corneal (HCE) and conjunctival epithelial (IM-ConjEpi) cells. CONV was conventionally extracted, while OPT(1–3) were produced by pressurized liquid extraction. Thanks to their improved activity, CONV and OPT3 (HT-enriched) were selected for dose-dependent studies. Cells were stimulated with tumor necrosis factor-α or ultraviolet-B radiation, measuring interleukin (IL)-1β, IL-6, IL-8, and IL-17A as well as interferon γ-induced protein [IP]-10 secretion or intracellular ROS production, respectively. On HCE, both extracts and HT inhibited the secretion of most measured ILs, demonstrating a strong anti-inflammatory effect; while in IM-ConjEpi, all samples decreased IP-10 secretion. Moreover, HT, OL, and both extracts showed strong dose-dependent antioxidant activity in both cell lines. Compared with CONV, OPT3 was active at lower concentrations, demonstrating that intensified extraction techniques are selective towards targeted biomarkers. Hence, a high-value application as potential ocular surface therapy was proposed for the OP valorization.

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Section: Discussionmentioning

confidence: 99%

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

2021

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“…The effectiveness of the formulation was further confirmed by tissue immunostaining. Reduced expression of different inflammatory markers (VCAM-1, IL-6, ICAM-1, and TNF-α) was observed in tissues from diseased animals treated with the PEG/catechin complex, indicating an anti-inflammatory effect [103].…”

Section: Catechinmentioning

confidence: 95%

“…This formulation strategy exploits the formation of hydrogen between the ether oxygen present in the PEG polymeric chain and the catechol group that is part of the structure of catechin. Catechin formulated in this way was tested as a potential treatment for DED in NOD.B10-H2b mice exposed to desiccating stress to develop experimental DED [103]. The complex PEG/catechin topically administered was able to prevent conjunctival goblet cells from deterioration, as demonstrated by the number of goblet cells recovered in DED-treated animals compared to untreated control animals.…”

Section: Catechinmentioning

confidence: 99%

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

2021

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Nature has become one of the main sources of exploration for researchers that search for new potential molecules to be used in therapy. Polyphenols are emerging as a class of compounds that have attracted the attention of pharmaceutical and biomedical scientists. Thanks to their structural peculiarities, polyphenolic compounds are characterized as good scavengers of free radical species. This, among other medicinal effects, permits them to interfere with different molecular pathways that are involved in the inflammatory process. Unfortunately, many compounds of this class possess low solubility in aqueous solvents and low stability. Ocular pathologies are spread worldwide. It is estimated that every individual at least once in their lifetime experiences some kind of eye disorder. Oxidative stress or inflammatory processes are the basic etiological mechanisms of many ocular pathologies. A variety of polyphenolic compounds have been proved to be efficient in suppressing some of the indicators of these pathologies in in vitro and in vivo models. Further application of polyphenolic compounds in ocular therapy lacks an adequate formulation approach. Therefore, more emphasis should be put in advanced delivery strategies that will overcome the limits of the delivery site as well as the ones related to the polyphenols in use. This review analyzes different drug delivery strategies that are employed for the formulation of polyphenolic compounds when used to treat ocular pathologies related to oxidative stress and inflammation.

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“…Because hydrogen can selectively neutralize cytotoxic reactive oxygen species and reduce harmful inflammation, local instillation, or IVS has been used to treat local injuries and chronic inflammation 92 . As an ocular antiinflammatory drug, hydrogen can also significantly reduce the circulating levels of a variety of proinflammatory cytokines (e.g., IL-1β, IL-6, ligand 2 (CCL2), and tumor necrosis factor-α) and ameliorate the accumulation of activated microglia 93 .…”

Section: Treatment Of Eye Diseasesmentioning

confidence: 99%

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

et al. 2021

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Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.

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Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eye therapeutics

Cited by 37 publications

References 43 publications

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

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