Catechol functionalized chitosan/active peptide microsphere hydrogel for skin wound healing

Zhang, Dongying; Ouyang, Qianqian; Zhang, Hu; Lu, Sitong; Quan, Wei-Yan; Li, Puwang; Chen, Yu; Li, Sidong

doi:10.1016/j.ijbiomac.2021.01.157

Cited by 74 publications

(44 citation statements)

References 62 publications

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“…Ouyang et al prepared a chitosan (CS)–tilapia marine peptides hydrogel with antibacterial activity, and evaluated its effect on burn skin healing in rabbits ( Ouyang et al, 2018 ). Besides, a recent study showed that catechol functionalized CS/β-glycerophosphate (β-GP)/oyster peptide microspheres hydrogel with favorable biosafety promoted skin wound healing in mice by inhibiting inflammatory factors and up-regulating Ki-67 and VEGF expressions ( Zhang et al, 2021 ). The aforementioned studies confirm that hydrogel scaffolds loaded with bioactive proteins/peptides appear to be a promising alternative therapy for skin wounds.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways

et al. 2022

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Skin wound healing is a principal clinical challenge, and it is necessary to develop effective alternative treatments. Excessive inflammatory response is linked to delayed healing. This study was the first to report a multi-functional chitosan/sodium alginate/velvet antler blood peptides (VBPs) hydrogel (CAVBPH) and explore its potential mechanism to promote wound healing. The results showed that CAVBPH possessed desirable characteristics including thermo-sensitivity, antioxidation, antibacterial activity, biosafety, VBPs release behavior, etc., and significantly accelerated skin wound healing in mice. Specifically, the CAVBPH treatment enhanced cell proliferation, angiogenesis, and extracellular matrix (ECM) secretion, and also relieved inflammation at the wound site compared to the PBS-treated group and blank hydrogel scaffold-treated group. Mechanistically, the efficacy of CAVBPH might be related to the activation of the PI3K/AKT/mTOR and SIRT1/NF-κB pathways. Overall, CAVBPH seems to be a promising therapy for skin repair, probably relying on the abundant short-chain peptides in VBPs.

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Section: Introductionmentioning

confidence: 99%

Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways

et al. 2022

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“…Several studies indicated that polymeric particles in the range of hundred nanometer to few micrometer sizes can be used in a wide range of biomedical applications. Zhang et al reported that the 1 to 10 μm size range of chitosan/peptide microspheres made it a promising biomaterial for wound healing applications [25]. In another study, Anderson et al also observed that polymeric microparticles with nearly 3 nm particle size could be used as a DNA delivery system [26].…”

Section: Resultsmentioning

confidence: 99%

Poli(Rutin) micro/nanogels for biomedical applications

Şahiner¹,

Suner²

2021

Hittite J. Sci. Eng.

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I nterest in flavonoids, which are phenolic compounds, has grown with the French paradox. Interest in bioflavonoids has increased based on Mediterranean culture, which includes a diet rich in phenol directly proportional to high fat with an inverse relationship with the risk of heart attack. Flavonoids are widely used in the food industry due to antioxidant and antimicrobial properties. Flavonoids are known to affect many biofunctions such as lowering blood pressure and having anti-inflammatory, hypocholesterolemic, anticancer platelet stabilizer, antiallergic, antidepressant and blood clotting properties [1,2]. Rutin is a known flavonoid and has two sugar molecules in its structure. Rutin's chemical name is quercetin-3-remnosyl glucoside [3]. It is present in many fruits and vegetables such as onion, tea, apple, parsley, citrus, sage, and grape [4]. It is used in the food, cosmetics, and even pharmacology industries

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“…Chitosan hydrogels are mostly dedicated to skin wound healing [252][253][254][255][256][257][258][259], but also find application as biomaterial applied to bone regeneration [260], spinal cord regeneration [261] or heart disease [262].…”

Section: Hydrogelsmentioning

confidence: 99%

“…The hydrogel constructed with oxidized chitosan and amidated pectin design by Amirian et al [253] exhibited interesting swelling properties, gelation time and degradability. Despite the chemical description, biological results are required for complete system characterization.…”

Section: Hydrogelsmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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Catechol functionalized chitosan/active peptide microsphere hydrogel for skin wound healing

Cited by 74 publications

References 62 publications

Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways

Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promoted Wound Healing by Regulating PI3K/AKT/mTOR and SIRT1/NF-κB Pathways

Poli(Rutin) micro/nanogels for biomedical applications

Chitosan as an Underrated Polymer in Modern Tissue Engineering

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