We discuss the collaboration support of loosely coupled Smart Systems through configurable hyper-frameworks. Based on the system-of-systems (SoS) paradigm, in this article, we propose the model of a novel extendible conceptual framework with domain-specific moderation support for model-based simulations and the engineering of complex heterogeneous systems. The domain knowledge meta-model and corresponding management enterprise architecture enable the creation of template-based specializations. The proposed SoS conceptual framework meta-model represents an initial framework prototype that supports modeling, simulation, analysis, and utilization of dynamic architecting of heterogeneous SoS configurations. A Smart-Habitat concept encapsulating Smart-Area, Smart-City, Smart-Lot, Smart-Building, and Smart-Unit abstractions illustrate the frameworks’ applicability. The proposed SoS conceptual framework represents the initial conceptual support for modeling, simulation, analysis, and dynamic architecting of heterogeneous SoS configurations. We plan to refine the component architecture meta-model, specify a language workbench with Domain-Specific Orchestration Language support, and verify the configuration-based simulation manifest creation. These actions lead to the framework’s next stage, an operational framework (OF) instance, as a transitional artifact to the aimed software framework (SwF) counterpart.