Catharanthus roseus leaf extract-synthesized chitosan nanoparticles for controlled in vitro release of chloramphenicol and ketoconazole

Nagaonkar, Dipali; Gaikwad, Swapnil; Rai, Mahendra

doi:10.1007/s00396-015-3538-3

Cited by 37 publications

(24 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CSNPs and ZnONPs were synthesized according to the method of Dipali et al [ 11 ] with minor modifications. In brief, the chitosan-TPP mixture was obtained by dissolving 0.8 g of sodium tripolyphosphate (TPP) (Aladdin Industrial Co., Shanghai, China) in 100 mL of chitosan solution, (Sinopharm chemical Regent Co., Ltd., China) which were prepared by adding about 1.5 g of chitosan (C 6 H 11 NO 4 ) n from shrimp shells, ≥75% (deacetylated) in 200 mL of 2% acetic acid solution and then stirring under continuous magnetic for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, a high number of polyphenols, especially flavonoids [ 8 ] in tomato make it a good candidate for synthesizing nanoparticles. In addition, unlike red tomatoes, green tomato is rich in alkaloids and contain a high amount of ascorbic acid [ 9 , 10 ], the former was used as a biogenic stabilizer during the synthesis of chitosan nanoparticles (CSNPs) [ 11 ], while the latter plays a vital role in the production of zinc oxide nanoparticles (ZnONPs) [ 12 ]. Recently, numerous studies have demonstrated that the natural biopolymer chitosan and its derivative, as well as metal nanoparticles such as Ag, ZnO, TiO 2 , MgO, and CuO, have strong antibacterial activity against a variety of bacterial pathogen [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioinspired Green Synthesis of Chitosan and Zinc Oxide Nanoparticles with Strong Antibacterial Activity against Rice Pathogen Xanthomonas oryzae pv. oryzae

et al. 2020

View full text Add to dashboard Cite

Bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most devastating diseases, resulting in significant yield losses in rice. The extensive use of chemical antibacterial agents has led to an increase the environmental toxicity. Nanotechnology products are being developed as a promising alternative to control plant disease with low environmental impact. In the present study, we investigated the antibacterial activity of biosynthesized chitosan nanoparticles (CSNPs) and zinc oxide nanoparticles (ZnONPs) against rice pathogen Xoo. The formation of CSNPs and ZnONPs in the reaction mixture was confirmed by using UV-vis spectroscopy at 300–550 nm. Moreover, CSNPs and ZnONPs with strong antibacterial activity against Xoo were further characterized by scanning and transmission electron microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction. Compared with the corresponding chitosan and ZnO alone, CSNPs and ZnONPs showed greater inhibition in the growth of Xoo, which may be mainly attributed to the reduction in biofilm formation and swimming, cell membrane damage, reactive oxygen species production, and apoptosis of bacterial cells. Overall, this study revealed that the two biosynthesized nanoparticles, particularly CSNPs, are a promising alternative to control rice bacterial disease.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioinspired Green Synthesis of Chitosan and Zinc Oxide Nanoparticles with Strong Antibacterial Activity against Rice Pathogen Xanthomonas oryzae pv. oryzae

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hence, it can be assumed that the sample MP5700 formed a core-shell structure composed of a polyelectrolyte-rich shell and a polyelectrolyte-poor core (Figure 6a). Previously, Grant et al [44] showed a similar structure prepared using mixtures of chitosan and sorbitan monolaurate without a cross-linker. The sample MP5700 was found to possess a low percentage of entrapped protein and result in a rapid initial BSA release owing to significant destruction of its non-stabilized shell.…”

Section: Role Of the Surfactant And Proposed Structure Of The Micropamentioning

confidence: 99%

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

et al. 2020

View full text Add to dashboard Cite

Microparticles, aimed for oral protein and peptide drug delivery, were prepared via emulsion cross-linking using citric acid as cross-linker and polyglycerol polyricinoleate as surfactant. A comparative study of the interaction between chitosan and citric acid and its effect on the resulting microparticle properties was performed using different chitosan-to-cross-linker mass ratios and pH-values during fabrication of the microparticles. Non-cross-linked and cross-linked microparticles were studied in terms of size (4–12 μm), zeta potential (−15.7 to 12.8 mV), erosion (39.7–75.6%), a model protein encapsulation efficiency (bovine serum albumin) (6.8–27.6%), and loading capacity (10.4–40%). Fourier transform infrared spectroscopy and X-ray diffraction confirmed the ionic interaction between the protonated amine groups of chitosan and the carboxylate ions of the cross-linking agent. Scanning electron microscopy revealed that the non-cross-linked microparticles had an uneven shape with wrinkled surfaces, while the cross-linked formulations were spherical in shape with smooth surfaces. On the basis of these data, the role of the surfactant and microparticle structure on the release mechanism was proposed. Control of the microparticle shape and release mechanisms is expected to be crucial in developing carriers for the controlled delivery of proteins and peptides.

show abstract

“…Chitosan is an amino polysaccharide molecule. It has strongly positive electrostatic charge which attracts strongly the negatively charged molecules [9]. Chitosan nanoparticles (NPs) have photonic applications such as drug delivery, cell imaging, gene therapy, photothermal therapy, cancer diagnosis and cell imaging [7].…”

Section: Introductionmentioning

confidence: 99%

Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser

et al. 2019

View full text Add to dashboard Cite

Chitosan-tripolyphosphate nanoparticles (C-TPP NPs) were synthesized to investigate their cytotoxicity against colon cancer cells (Caco2 cells) in the absence and the presence of a near-infrared (NIR) laser to evaluate their influence in cancer detection using the NIR laser and to evaluate the NIR laser on cancer treatment. The synthesized NPs were characterized by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), zeta potential (ZP), and transmission electronic microscope (TEM). The cytotoxicity was analyzed by the MTT test and the cell viability was assessed using the Trypan blue method. C-TPP NPs showed increased cytotoxicity and decreased cell viability against Caco2 cells. Upon laser exposure only, the cell viability decreased. The C-TPP NPs appeared to have a shining light on the cancerous cells which were photographed under the inverted microscope.

show abstract

Catharanthus roseus leaf extract-synthesized chitosan nanoparticles for controlled in vitro release of chloramphenicol and ketoconazole

Cited by 37 publications

References 21 publications

Bioinspired Green Synthesis of Chitosan and Zinc Oxide Nanoparticles with Strong Antibacterial Activity against Rice Pathogen Xanthomonas oryzae pv. oryzae

Bioinspired Green Synthesis of Chitosan and Zinc Oxide Nanoparticles with Strong Antibacterial Activity against Rice Pathogen Xanthomonas oryzae pv. oryzae

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser

Contact Info

Product

Resources

About