Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

Jevnikar, Zala; Rojnik, Matija; Jamnik, Polona; Doljak, Bojan; Fonović, Urša Pečar; Kos, Janko

doi:10.1074/jbc.m112.436394

Cited by 61 publications

(45 citation statements)

References 48 publications

(50 reference statements)

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“…Along with prosaposin, several other lysosomal proteins were upregulated in gallbladder cancer including cathepsin Z (CTSZ) (2.2-fold), ganglioside GM2 activator (GM2A) (1.9-fold), cathepsin H (CTSH) (1.9-fold), gamma-glutamyl hydrolase (GGH) (1.7-fold) and alpha-N-acetylgalactosaminidase (NAGA) (1.7-fold). Cathepsin Z and H are associated with metastasis and migration [29,30]. …”

Section: Resultsmentioning

confidence: 99%

Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics

Sahasrabuddhe

Barbhuiya

Bhunia

et al. 2014

Biochemical and Biophysical Research Communications

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Gallbladder cancer is an uncommon but lethal malignancy with particularly high incidence in Chile, India, Japan and China. There is a paucity of unbiased large-scale studies investigating molecular basis of gallbladder cancer. To systematically identify differentially regulated proteins in gallbladder cancer, iTRAQ-based quantitative proteomics of gallbladder cancer was carried out using Fourier transform high resolution mass spectrometry. Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z and cathepsin H. Downregulated proteins included serine protease HTRA1 and transgelin, which have been reported to be downregulated in several other cancers. Novel biomarker candidates including prosaposin and transgelin were validated to be upregulated and downregulated, respectively, in gallbladder cancer using tissue microarrays. Our study provides the first large scale proteomic characterization of gallbladder cancer which will serve as a resource for future discovery of biomarkers for gallbladder cancer.

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Section: Resultsmentioning

confidence: 99%

Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics

Sahasrabuddhe

Barbhuiya

Bhunia

et al. 2014

Biochemical and Biophysical Research Communications

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“…In contrast to animals, little is known about the role of cathepsins in plant PCD, except that cathepsin B proteases have been shown to act as pro-death components during hypersensitive response [29],[30]. Apart from regulating neurotransmitters [31] and tumor progression [32] in animals, the physiological role of cathepsin H-type proteases remained poorly understood. In the present work, we demonstrate that NtCP14 is a cathepsin H-type protease with a preference for substrate Bz-FVR-AMC and is a positive regulator of suspensor PCD.…”

Section: Discussionmentioning

confidence: 99%

A Bipartite Molecular Module Controls Cell Death Activation in the Basal Cell Lineage of Plant Embryos

et al. 2013

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“…Cathepsins participate in a number of processes in healthy cells, but have also been reported to be involved in certain pathological processes, including cancer progression (4)(5)(6)(7). In a number of cancer types, increased expression of cysteine cathepsins and alterations in their subcellular trafficking were reported (8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Cathepsin L is involved in proliferation and invasion of ovarian cancer cells

Zhang

Wei

Shen

et al. 2014

Molecular Medicine Reports

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Abstract. Cathepsin L (CTSL) is a lysosomal cysteine protease that has been found to be overexpressed in ovarian cancer (OC). The aim of the present study was to investigate the possible involvement of CTSL in the development of OC. In this study, RNA interference with a CTSL small hairpin RNA (CTSL-shRNA), and a plasmid carrying CTSL were used to identify the effects of this enzyme on the regulation of the malignant behavior of OC cells. OV-90 and SKOV3 human ovarian cancer cell lines were selected as cell models in vitro and in vivo. The results showed that downregulation of CTSL significantly inhibits the proliferative and invasive capability of SKOV3 cells, and that upregulation of CTSL in OV-90 cells leads to opposite effects. Compared with parental OC cells, cells in which CTSL was silenced exhibited a reduced capacity to develop into tumors in nude mice, while the growth of tumor xenografts derived from these cells was markedly constrained. In conclusion, the results suggested that CTSL contributes to the proliferation and metastasis of OC, and that CTSL may be a novel molecular target for OC treatment.

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Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

Cited by 61 publications

References 48 publications

Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics

Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics

A Bipartite Molecular Module Controls Cell Death Activation in the Basal Cell Lineage of Plant Embryos

Cathepsin L is involved in proliferation and invasion of ovarian cancer cells

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