Cathode Ray Treatment for Lymphomas Involving the Skin

Hare, Hugh F.; Fromer, John L.; Trump, John G.; Wright, K. A.; Anson, John

doi:10.1001/archderm.1953.01540120019004

Cited by 18 publications

(2 citation statements)

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“…Since total skin irradiation with fast electrons was first applied in 1953 [6] with a total dose of 600 rad, various dose schemes have been tried, but more recently it was shown by F uks et al [3] that a dose of about 3,500 rad gives the best results in mycosis fungoides. Although it is difficult to obtain a complete cure in all patients, these authors reported disease-free survivals of 3-14 years duration after a single course of electron therapy in about 10% of their patients.…”

Section: Discussionmentioning

confidence: 99%

“…During the last 20 years, several studies on total skin irradiation in mycosis fungoides have been published [3,5,6,10,12]. The Stanford group [3] has described the results obtained in the largest series so far (132 patients with mycosis fungoides) and they tentatively recommended agressive therapy in the form of total skin electron irradiation in the early stage of mycosis fun goides.…”

Section: Introductionmentioning

confidence: 99%

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Total Skin Electron Irradiation in Mycosis fungoides

Vloten¹,

Vermeij²,

Vroome³

1977

Dermatology

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Total skin irradiation with fast electrons (4 MeV, 3,500 rad) was applied in 10 cases of histologically proven mycosis fungoides without any signs of internal dissemination. The technique is described. Complete disappearance of both lesions and symptoms occurred in all patients after treatment. However, half of the patients relapsed after the initial irradiation and were subsequently treated with a booster dose of 1,000 rad 4 MeV electrons or with topical nitrogen mustard. Irradiation with fast electrons seems to be of great importance in the treatment of mycosis fungoides.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Total Skin Electron Irradiation in Mycosis fungoides

Vloten¹,

Vermeij²,

Vroome³

1977

Dermatology

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Lymphangioma-like Tumors in Kaposi's Sarcoma

Ronchese¹,

Kern²

1957

Arch Dermatol

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Prognostic signs and the management of the mycosis fungoides

Fuks

Bagshaw

Farber

1973

Cancer

190

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A total of 132 patients with biopsy‐proven mycosis fungoides were treated by total skin irradiation with 2.5 MeV electrons. In 58% a complete remission of cutaneous manifestations was observed. The rate of complete remission was dose‐dependent and was inversely dependent on the extent of disease. Fourteen patients had disease‐free survivals of 3–14 years following a single course of treatment, and may be considered as cured. Fifty‐six patients died, 52% of whom succumbed to extracutaneous involvement with disease. Extracutaneous involvement correlated with the extent of skin involvement, and with the presence of initial lymphadenopathy, and was associated with poor prognosis. A new staging classification is proposed which provides a rational basis for the introduction of new treatment modalities for the management of mycosis fungoides patients.

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Cathode Ray Treatment for Lymphomas Involving the Skin

Cited by 18 publications

References 1 publication

Total Skin Electron Irradiation in Mycosis fungoides

Total Skin Electron Irradiation in Mycosis fungoides

Lymphangioma-like Tumors in Kaposi's Sarcoma

Prognostic signs and the management of the mycosis fungoides

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