Cationic Polymeric Nanocapsules as a Strategy to Target Dexamethasone to Viable Epidermis: Skin Penetration and Permeation Studies

Beber, T.C.; Andrade, Diego Fontana de; Chaves, Paula dos Santos; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski; Beck, Ruy Carlos Ruver

doi:10.1166/jnn.2016.11670

Cited by 34 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These two types of polymers (ERL and ERS), with different permeabilities, are often used together in different proportions to achieve the target specific permeability and the desired rate of intestinal absorption. These polymers, alone or in blends, have been used in pharmaceutics for the development of micro [39,40] and nanoparticles [41][42][43][44], coated tablets [45] and mucoadhesive buccal films [46], among others, mainly to obtain sustained release delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

View full text Add to dashboard Cite

Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The optimized gel showed sustained drug release and boosted epidermal drug deposition and retention. Thus, dexamethasone-loaded cationic polymeric nanocapsule hydrogel can be used as a promising nanocarrier system for antipsoriatic therapy [ 90 ].…”

Section: Nanocarrier-mediated Delivery Of Tcs In Psoriasis and Admentioning

confidence: 99%

“… [ 86 ] Dexamethasone Interfacial deposition of preformed polymer Eudragit ® RS 100; Carbopol Ultrez ® 10 NF; caprylic/capric triglyceride; imidazolidinyl urea; triethanolamine; Polysorbate 80; acetone The Higuchi model reported a controlled drug release pattern. [ 90 ] Desonide Interfacial deposition of preformed polymer PCL; Sorbitan monostearate; Polysorbate 80; caprylic/capric triglycerides; acetone; Eudragit S100; Eudragit L100 In vitro drug release revealed a monoexponential and biexponential release profile, regardless of the type of drug release method. [ 91 ] Polymeric micelles Beclomethasone dipropionate Thin-film hydration technique Pluronic F127 (PL-F127); Synperonic PE/P84 (P84); Pluronic L121 (PL-L121); acetone; distilled water Better skin biocompatibility, minimal systemic drug circulation, and early tissue regeneration than marketed formulations.…”

Section: Nanocarrier-mediated Delivery Of Tcs In Psoriasis and Admentioning

confidence: 99%

Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review

Shetty

Sherje

2021

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Atopic dermatitis (AD) and psoriasis are highly prevalent, complex, chronic inflammatory skin diseases that immensly affect the patient’s quality of life. While there is no definitive cure for these conditions, suppressive medications aim at managing the symptoms of these diseases. The application of emollients accompanied by symptomatic anti-inflammatory therapy consisting of topical corticosteroids (TCS) is extensively employed for controlling the symptoms among general practitioners making this therapeutic class an indispensable pillar of dermatotherapeutics. The first TCS, hydrocortisone (HC) introduced in the early 1950s led to the development of different steroidal moieties of varying potencies by inducing chemical modifications to the basic steroid structure. The wide spectrum of the available range of formulations and potency provides flexibility to treat all patient groups, different phases of the diseases, and different anatomical sites. Conventional TCS therapy suffers from drawbacks such as low drug permeation and retention rate. Thus, novel nanoformulations have been developed to overcome these problems. This review provides an insight into the current state of nanocarrier-mediated topical delivery of corticosteroids monotherapy and combination therapy with special emphasis on targeting psoriasis and AD.

show abstract

“…EUD was selected to cover the positive surface of the nanocapsules to promote greater electrostatic interaction between the drug and the sublingual 31 and vaginal 32 mucosa, as epidermis membranes. 33 The effect of cationic nanocapsules has been described by our research group, including the development of PCL-and EUD-loaded Curcuma oil, which have been evaluated as experimental malaria treatments. Similar results were obtained with both formulations.…”

Section: Technological Evaluation Of Quinine-loaded Nanocapsulesmentioning

confidence: 99%

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Michels¹,

Maciel²,

Nakama³

et al. 2019

IJN

View full text Add to dashboard Cite

Introduction: The surface charge of nanoparticles, such as nanospheres (NS) and nanocapsules (NC), has been studied with the purpose of improving the in vivo performance of drugs. The aim of this study was to develop, characterize, and evaluate the in vitro antimalarial efficacy of NCP80 and NSP80 (polysorbate coated) or NCEUD and NSEUD (prepared with Eudragit RS 100) loading quinine (QN). Methods: Formulations were prepared by the nanoprecipitation method, followed by wide physicochemical characterization. Antimalarial activity in Plasmodium berghei-infected mice and populational pharmacokinetics (PopPK) in rats were evaluated. Results: The formulations showed a nanometric range (between 138 ± 3.8 to 201 ± 23.0 nm), zeta potential (mV) of −33.1 ± 0.7 (NCP80), −30.5 ± 1 (UNCP80), −25.5 ± 1 (NSP80), −20 ± 0.3 (UNSP80), 4.61 ± 1 (NCEUD), 14.1 ± 0.9 (UNCEUD), 2.86 ± 0.3 (NSEUD) and 2.84 ± 0.6 (UNSEUD), content close to 100%, and good QN protection against UVA light. There was a twofold increase in the penetration of QN into infected erythrocytes with NC compared to that with NS. There was a significant increase in t 1/2 for all NC evaluated compared to that of Free-QN, due to changes in Vdss. PopPK analysis showed that NCP80 acted as a covariate to Q (intercompartmental clearance) and V2 (volume of distribution in the peripheral compartment). For NCEUD, V1 and Q were modified after QN nanoencapsulation. Regarding in vivo efficacy, NCEUD increased the survival of mice unlike Free-QN. Conclusion: Cationic nanocapsules modified the pharmacology of QN, presenting a potential alternative for malaria treatment.

show abstract

Cationic Polymeric Nanocapsules as a Strategy to Target Dexamethasone to Viable Epidermis: Skin Penetration and Permeation Studies

Cited by 34 publications

References 0 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Contact Info

Product

Resources

About