Cationic Polymers and its Uses in Non-viral Gene Delivery Systems: A Conceptual Research

Uddin, Sarder Nasir; Islam, Kinza

doi:10.3923/tmr.2006.86.99

Cited by 6 publications

(1 citation statement)

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“…The physicochemical approaches have recently proposed for non-viral based delivery systems [40]. Non-viral vectors of delivery systems for gene therapy are less likely to induce an immune response in the system of biocompatible materials such as lipid, naked DNA, chromosomes, plasmid, cationic polymers, and conjugate complexes [41].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the development of gene delivery systems

2019

Biomater Res

352

206

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BackgroundGene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. The useful results of gene delivery systems depend open the adjustable targeting gene delivery systems. Some of successful gene delivery systems have recently reported for the practical application of gene therapy.Main bodyThe recent developments of viral gene delivery systems and non-viral gene delivery systems for gene therapy have briefly reviewed. The viral gene delivery systems have discussed for the viral vectors based on DNA, RNA and oncolytic viral vectors. The non-viral gene delivery systems have also treated for the physicochemical approaches such as physical methods and chemical methods. Several kinds of successful gene delivery systems have briefly discussed on the bases of the gene delivery systems such as cationic polymers, poly(L-lysine), polysaccharides, and poly(ethylenimine)s.ConclusionThe goal of the research for gene delivery system is to develop the clinically relevant vectors such as viral and non-viral vectors that use to combat elusive diseases such as AIDS, cancer, Alzheimer, etc. Next step research will focus on advancing DNA and RNA molecular technologies to become the standard treatment options in the clinical area of biomedical application.

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Section: Introductionmentioning

confidence: 99%