Cationic β-cyclodextrin-modified hybrid magnetic microspheres as chiral selectors for selective chiral absorption of dansyl amino acids

Wu, Jingwei; Su, Ping; Guo, Danhua; Huang, Jun; Yang, Yi

doi:10.1039/c4nj00030g

Cited by 28 publications

(23 citation statements)

References 37 publications

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“…Derivatization strategies not only increase the obtained sensitivity but might also improve the chiral recognition existing in the selectand‐selector system. Although there is a broad variety of derivatization reagents suitable to improve the detection sensitivity, off‐column derivatization with dansyl (DNS) group has been the derivatization agent of choice in recent years to detect chiral amino acids . Just two of the published articles reported the obtained LODs, these being 1–10 × 10 −7 M and 7–200 × 10 −7 M .…”

Section: Strategies To Enhance the Detection Sensitivitymentioning

confidence: 99%

Improving the sensitivity in chiral capillary electrophoresis

2015

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CE is known for being one of the most powerful analytical techniques when performing enantioseparations due to its numerous advantages such as excellent separation efficiency and extremely low solvents and reagents consumption, all of them derived from the capillary small dimensions. Moreover, it is worth highlighting that unlike in chromatographic techniques, in CE the chiral selector is generally within the separation medium instead of being attached to the separation column which makes the method optimization a more versatile task. Despite its numerous advantages, when using UV-Vis detection, CE lacks of sensitivity detection due to its short optical path length derived from the narrow separation capillary. This issue can be overcome by means of different approaches, either by sample treatment procedures or by in-capillary preconcentration techniques or even by employing detection systems more sensitive than UV-Vis, such as LIF or MS. The present review assembles the latest contributions regarding improvements of sensitivity in chiral CE published from June 2013 until May 2015, which follows the works included in a previous review reported by Sánchez-Hernández et al. [Electrophoresis 2014, 35, 12-27].

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Section: Strategies To Enhance the Detection Sensitivitymentioning

confidence: 99%

Improving the sensitivity in chiral capillary electrophoresis

2015

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“…Recently the preparation of a large number of CD-derivatives by MW-assisted CuAAC regioselective cycloadditions has been described. A selected series of derivatives are depicted in Scheme 10 : CD-acryloyl derivative [ 60 – 61 ], β-CD/dye derivatives [ 31 , 62 – 64 ], CD-ionic liquid hybrids [ 65 – 66 ], CD-based iminosugar conjugates [ 67 ], water-soluble CD homo- and heterodimers [ 68 – 69 ], trimers [ 70 – 71 ] and oligomers [ 72 ] of α-, β- and γ-CD have all been successfully produced. This wide variety of compounds was obtained in good to excellent yield under MW irradiation (from 20 min to 3 h at 75 °C to 100 °C).…”

Section: Reviewmentioning

confidence: 99%

Enabling technologies and green processes in cyclodextrin chemistry

Cravotto¹,

Caporaso²,

Jicsinszky³

et al. 2016

Beilstein J. Org. Chem.

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SummaryThe design of efficient synthetic green strategies for the selective modification of cyclodextrins (CDs) is still a challenging task. Outstanding results have been achieved in recent years by means of so-called enabling technologies, such as microwaves, ultrasound and ball mills, that have become irreplaceable tools in the synthesis of CD derivatives. Several examples of sonochemical selective modification of native α-, β- and γ-CDs have been reported including heterogeneous phase Pd- and Cu-catalysed hydrogenations and couplings. Microwave irradiation has emerged as the technique of choice for the production of highly substituted CD derivatives, CD grafted materials and polymers. Mechanochemical methods have successfully furnished greener, solvent-free syntheses and efficient complexation, while flow microreactors may well improve the repeatability and optimization of critical synthetic protocols.

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“…reported a type of chiral zirconia magnetic nanomaterial and demonstrated an effective separation of different kinds of chiral drugs. Yang and co‐workers prepared a series of magnetic microspheres modified with dendrimers, human serum albumin (HAS), or β‐cyclodextrin (β‐CD) polymer for the chiral separation of drugs and amino acids. Zou et al.…”

Section: Introductionmentioning

confidence: 99%

6‐TIPS‐β‐Cyclodextrin‐Modified Fe₃O₄ for Facile Enantioseparation of 1‐(1‐Naphthyl)ethylamine

Wang

Liang

Ding

et al. 2016

Chemistry An Asian Journal

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A new type of chiral magnetic nanoparticle was prepared from covalently linked magnetic nanoparticles (Fe O ) and heptakis-(6-O-triisopropylsilyl)-β-cyclodextrin (6-TIPS-β-CD). The resulting selectors (TIPS-β-CD-MNPs) combined the good magnetic properties Fe O and efficient chiral recognition ability of 6-TIPS-β-CD. The enantioselectivity of TIPS-β-CD-MNPs towards 1-(1-naphthyl)ethylamine was six times higher than that of the parent β-CD modified Fe O particles.

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Cationic β-cyclodextrin-modified hybrid magnetic microspheres as chiral selectors for selective chiral absorption of dansyl amino acids

Abstract: Chiral selective magnetic microspheres based on imidazolium cationic-modified β-CD derivatives have been developed for direct enantioseparation of dansyl amino acids.

Cited by 28 publications

References 37 publications

Improving the sensitivity in chiral capillary electrophoresis

Improving the sensitivity in chiral capillary electrophoresis

Enabling technologies and green processes in cyclodextrin chemistry

6‐TIPS‐β‐Cyclodextrin‐Modified Fe₃O₄ for Facile Enantioseparation of 1‐(1‐Naphthyl)ethylamine

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Cationic β-cyclodextrin-modified hybrid magnetic microspheres as chiral selectors for selective chiral absorption of dansyl amino acids

Abstract: Chiral selective magnetic microspheres based on imidazolium cationic-modified β-CD derivatives have been developed for direct enantioseparation of dansyl amino acids.

Cited by 28 publications

References 37 publications

Improving the sensitivity in chiral capillary electrophoresis

Improving the sensitivity in chiral capillary electrophoresis

Enabling technologies and green processes in cyclodextrin chemistry

6‐TIPS‐β‐Cyclodextrin‐Modified Fe3O4 for Facile Enantioseparation of 1‐(1‐Naphthyl)ethylamine

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6‐TIPS‐β‐Cyclodextrin‐Modified Fe₃O₄ for Facile Enantioseparation of 1‐(1‐Naphthyl)ethylamine