CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching

Feng, Zhi Gang; Zhao, Yijie; Li, Tingting; Nie, Wang; Yang, Xiaoyan; Wang, Xinjian; Wu, Jiaxi; Liao, Jun; Zou, Yan

doi:10.1016/j.celrep.2020.108101

Cited by 26 publications

(58 citation statements)

References 58 publications

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“…For example, PVD can develop normally with catp-8/P5A-ATPase function present in either neurons or muscle. This finding is in contrast to findings by Feng et al who could rescue catp-8 defects by transgenic expression of catp-8 in neurons, but not in muscle [23]. One possible explanation for this discrepancy is different levels in transgene expression (we use a single copy transgenes for epidermal expression whereas Feng et al utilized multi copy transgenes [23]).…”

Section: Functional Redundancy Of Catp-8/p5a-atpase In Neuronal Patterningcontrasting

confidence: 80%

“…This finding is in contrast to findings by Feng et al who could rescue catp-8 defects by transgenic expression of catp-8 in neurons, but not in muscle [23]. One possible explanation for this discrepancy is different levels in transgene expression (we use a single copy transgenes for epidermal expression whereas Feng et al utilized multi copy transgenes [23]). This hypothesis is supported by the fact that the Menorin pathway is known to be dosage sensitive, and can be both positively and negatively regulated [57,58].…”

Section: Functional Redundancy Of Catp-8/p5a-atpase In Neuronal Patterningcontrasting

confidence: 80%

“…It should be noted that Wnt signaling is also required for correct axon guidance of both HSN and PVQ axons at the midline [39,56] and, at least for the latter cellular context, has been shown to function in parallel with Netrin signaling [56]. [23]). This hypothesis is supported by the fact that the Menorin pathway is known to be dosage sensitive, and can be both positively and negatively regulated [57,58].…”

Section: Catp-8/p5a Atpase Is Required For Localization Of Some Cell mentioning

confidence: 99%

“…Taken together, these results suggest that the CATP-8/P5A-ATPase functions in multiple pathways during neural patterning and is important for correct localization of transmembrane cell surface proteins. While this study was in progress, two studies reporting a function for catp-8/P5A-ATPase in PVD patterning in C. elegans were published [23,24]. Feng et al suggested a role for catp-8/P5A-ATPase in targeting of DMA-1/LRR-TM in dendrites [23] and Qin et al suggested that catp-8 was important for ER homeostasis by preventing mistargeting of mitochondrial proteins independently of ERassociated degradation (ERAD) [24].…”

Section: Introductionmentioning

confidence: 95%

“…While this study was in progress, two studies reporting a function for catp-8/P5A-ATPase in PVD patterning in C. elegans were published [23,24]. Feng et al suggested a role for catp-8/P5A-ATPase in targeting of DMA-1/LRR-TM in dendrites [23] and Qin et al suggested that catp-8 was important for ER homeostasis by preventing mistargeting of mitochondrial proteins independently of ERassociated degradation (ERAD) [24]. Similarly, a crystal structure of the yeast homolog Spf1 in conjunction with biochemical studies suggested a role for P5A-ATPases in ER and mitochondrial quality control [25].…”

Section: Introductionmentioning

confidence: 99%

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The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

Tang

Trivedi

Freund

et al. 2021

Preprint

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The assembly of neuronal circuits involves the migrations of neurons from their place of birth to their final location in the nervous system, as well as the coordinated growth and patterning of axons and dendrites. In screens for genes required for patterning of the nervous system, we identified the catp-8/P5A-ATPase as an important regulator of neural patterning. P5A-ATPases are part of the P-type ATPases, a family of proteins known to serve a conserved function as transporters of ions, lipids and polyamines in unicellular eukaryotes, plants, and humans. While the function of many P-type ATPases is relatively well understood, the function of P5A-ATPases in metazoans remained elusive. We show here, that the Caenorhabditis elegans ortholog catp-8/P5A-ATPase is required for specific aspects of nervous system development. Specifically, the catp-8/P5A-ATPase serves functions in shaping the elaborately sculpted dendritic trees of somatosensory PVD neurons. Moreover, catp-8/P5A-ATPase is required for axonal guidance and repulsion at the midline, as well as embryonic and postembryonic neuronal migrations. Interestingly, not all axons at the midline require catp-8/P5A-ATPase , although the axons run in the same fascicles and navigate the same space. Similarly, not all neuronal migrations require catp-8/P5A-ATPase . A CATP -8/P5A-ATPase reporter is localized to the ER in most if not all tissues and catp-8/P5A-ATPase can function both cell-autonomously and non-autonomously to regulate neuronal development. Genetic analyses establish that catp-8/P5A-ATPase can function in multiple pathways, including the Menorin pathway, previously shown to control dendritic patterning in PVD, and Wnt signaling, which functions to control neuronal migrations. Lastly, we show that catp-8/P5A-ATPase is required for localizing select transmembrane proteins necessary for dendrite morphogenesis. Collectively, our studies suggest that catp-8/P5A-ATPase serves diverse, yet specific roles in different genetic pathways, and may be involved in the regulation or localization of transmembrane proteins to specific subcellular compartments.

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Section: Functional Redundancy Of Catp-8/p5a-atpase In Neuronal Patterningcontrasting

confidence: 80%

Section: Functional Redundancy Of Catp-8/p5a-atpase In Neuronal Patterningcontrasting

confidence: 80%

Section: Catp-8/p5a Atpase Is Required For Localization Of Some Cell mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

Tang

Trivedi

Freund

et al. 2021

Preprint

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Roles of glycoconjugates in neural patterning in C. elegans

Bülow

2021

Current Topics in Developmental Biology

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An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins

et al. 2020

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CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching

Cited by 26 publications

References 58 publications

The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

Roles of glycoconjugates in neural patterning in C. elegans

An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins

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