Cattle Bile Arisaema Aqueous Extracts Protect Against Febrile Seizures in Rats Through Regulating Neurotransmitters and Suppressing Neuroinflammation

Su, Fazhi; Bai, Chen-Xi; Luo, Yu-Meng; Zhang, Wensen; Cui, Na; Wang, Yangyang; Sun, Yanping; Zhu, Wenbo; Zhao, Mingyang; Yang, Bing‐You; Kuang, Hai‐Xue; Wang, Qiuhong

doi:10.3389/fphar.2022.889055

Cited by 7 publications

(1 citation statement)

References 68 publications

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“…It has been determined that HMGB1/TLR4/NF-κB inflammatory network and its downstream mediators (IL-1β and TNF-α) as well as NLRP3 inflammasomemediated neuroinflammatory responses in the brain (Su et al, 2022;Xu et al, 2023). Investigation on ASD patients reveals a higher level of pro-inflammatory cytokines, including IL-1β and TNF-α (Chan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Reisi‐Vanani,

Lorigooini,

Bijad

et al. 2023

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is the fastest‐growing neurodevelopmental disease throughout the world. Neuro‐immune responses from prenatal to adulthood stages of life induce developmental defects in synaptic signaling, neurotransmitter imbalance, and even structural changes in the brain. In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic‐like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45–60, behavioral tests related to autistic‐like behaviors including three‐chamber sociability, Morris water maze (MWM), shuttle box, resident‐intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF‐α, IL‐1β, TLR4, HMGB1, and NLRP3 was assessed in the hippocampus using RT‐PCR. Results showed that MS mice exerted impaired sociability preference, repetitive behaviors, impaired passive avoidance, and spatial memories. The gene expression of inflammatory mediators significantly increased in the hippocampi of MS mice. We concluded that MS stress probably via activating of the HMGB1/TLR4 signaling cascade in the hippocampus induced autistic‐like behaviors in mice.

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Section: Discussionmentioning

confidence: 99%

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Reisi‐Vanani,

Lorigooini,

Bijad

et al. 2023

Intl J of Devlp Neuroscience

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Revealing the optimal traditional processing methods and its protective effects against febrile seizures of Arisaema cum bile

Zhang,

Wu,

Wang

et al. 2024

Biomedical Chromatography

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Arisaema cum bile (known as Dan Nanxing in Chinese, DNX) is a herbal medicine used for treating febrile seizure (FS), which commonly prepared by using Arisaematis Rhizoma and animal bile. This study was designed to explore the optimal processing time of DNX and its potential mechanism on the anti‐FS effect. A total of 17 volatile organic compounds (VOCs) were the characteristic ones to distinguish different fermentation stages of DNX by using gas chromatography–ion mobility spectrometry (GC‐IMS), such as 2‐heptanone monomer, and heptanal monomer. DNX with fermentation for 3 months had an obvious pattern of VOCs with others, which could be regarded as the optimal fermentation time. The Enterococcus and Staphylococcus might be the core bacteria on the production of VOCs. Additionally, DNX (2.8 g/kg, p.o.) reversed hot water bath‐induced FSs of rats, as indicated by increased seizure latency and decreased seizure duration time. It also prevented hippocampal neuronal loss, increased GABAAR, and decreased GRIA1 expression. At the genus level, relative abundance of Enterococcus and Akkermansia were enriched after DNX treatment. These findings suggested that fermentation for 3 months might be the optimal process time for DNX, and DNX possess an anti‐FS effect through regulating neurotransmitter disorder and gut microbiota.

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Identifying the active antioxidant ingredients in Arisaema Cum Bile aqueous extract on the basis of spectrum-effect relationships

DENG,

LEI,

et al. 2024

Chinese Journal of Analytical Chemistry

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Cattle Bile Arisaema Aqueous Extracts Protect Against Febrile Seizures in Rats Through Regulating Neurotransmitters and Suppressing Neuroinflammation

Cited by 7 publications

References 68 publications

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Revealing the optimal traditional processing methods and its protective effects against febrile seizures of Arisaema cum bile

Identifying the active antioxidant ingredients in Arisaema Cum Bile aqueous extract on the basis of spectrum-effect relationships

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