Caudatan A, an undescribed human kidney-type glutaminase inhibitor with tetracyclic flavan from Ohwia caudata

Sun, Yiwei; Feng, Xiaohe; Liu, Xuanli; Qian, Cheng; Che, Xin; Cao, Fei; Jin, Sanshan; Meng, Dali

doi:10.1016/j.phytochem.2018.04.013

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…The known compounds ( Figure 1) were identified as isoswertisin ( 4 ), [14] taxifolin ( 5 ), [15] caudatan B ( 6 ), [16] (2 R ,4 R )‐2‐(5‐hydroxy‐2‐methylphenyl)‐8‐(3‐methylbut‐2‐en‐1‐yl)‐4‐(l‐oxidaneyl)chromane‐3,7‐diol ( 7 ), [17] 8‐prenykaempferol ( 8 ), [18] 2‐(2,4‐dihydroxyphenyl)‐3,5‐dihydroxy‐7‐methoxy‐8‐(3‐methylbut‐2‐en‐1‐yl)chroman‐4‐one ( 9 ), [19] 8‐prenylquercretin ( 10 ), [20] citrusinol ( 11 ), [21] pulcheloid B ( 12 ), [22] yokovanol ( 13 ), [23] apigenin ( 14 ), [24] 8‐dimethylallyltaxifolin ( 15 ), [25] genistein ( 16 ), [26] naringenin ( 17 ), [27] shuterin ( 18 ), [28] kaempferol ( 19 ), [29] aromadendrin ( 20 ), [30] luteolin ( 21 ), [31] quercetin ( 22 ) [29] by comparing their spectrascopic data with those from previous reports.…”

Section: Resultsmentioning

confidence: 99%

Lignans and Flavonoids from Cajanus cajan (L.) Millsp. and Their α‐Glucosidase Inhibitory Activities

Zhang

Lei

Liu

et al. 2022

Chemistry & Biodiversity

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A pair of new lignan conformers (1 -2), one new flavonoid glycoside (3), as well as nineteen known compounds were purified from the twigs and leaves of Cajanus cajan (L.) Millsp.. The planar structures of the unknown compounds were determined via NMR and high-resolution mass spectrometry, while their absolute configurations were elucidated via comparison between their experimental and calculated electronic circular dichroism (ECD) values. All the isolated compounds were assayed for their α-glucosidase inhibitory activities. The results demonstrated that compounds 8-12, 15 -16, 18-19, 21-22 had strong inhibition activities, with compound 10 (IC 50 = 0.4 � 0.21 μM) most active. The structure-activity relationships were preliminarily summarized. Enzyme kinetics showed that compounds 8, 9, 15-16, 18 -19, 21-22 were non-competitive inhibitors and compounds 10-12 were anti-competitive ones.

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Section: Resultsmentioning

confidence: 99%

Lignans and Flavonoids from Cajanus cajan (L.) Millsp. and Their α‐Glucosidase Inhibitory Activities

Zhang

Lei

Liu

et al. 2022

Chemistry & Biodiversity

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“…Ohwia caudata ( O. caudata ), formerly known as Desmodium caudatum , belongs to the Leguminosae family and is widely found in East African countries. Recently, several studies have revealed that O. caudata displays a wide variety of biological effects against oxidative stress, inflammation, respiratory viruses, Alzheimer's disease, fever, and tumor growth [ [18] , [19] , [20] , [21] , [22] , [23] ]. Although O. caudata has therapeutic effects against several illnesses, research on the therapeutic effects of the aqueous extract of O. caudata is lacking.…”

Section: Introductionmentioning

confidence: 99%

Ohwia caudata aqueous extract attenuates senescence in aging adipose-derived mesenchymal stem cells

Ho,

Tsai,

Debakshee

et al. 2024

Heliyon

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“…Moreover, Ohwia caudata can treat Alzheimer's disease and inhibit Influenza A Virus infection 23,25 . Caudatan A, derived from Ohwia caudata , can be used for cancer prevention as it is a potential inhibitor of human kidney‐type glutaminase, which is over‐expressed in many cancer cells to up‐regulate oncogenes and raise the rate of cell proliferation 26 . However, the protective ability of Ohwia caudata against other type of stress in stem cells, has not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

“…23,25 Caudatan A, derived from Ohwia caudata, can be used for cancer prevention as it is a potential inhibitor of human kidney-type glutaminase, which is overexpressed in many cancer cells to up-regulate oncogenes and raise the rate of cell proliferation. 26 However, the protective ability of Ohwia caudata against other type of stress in stem cells, has not been investigated yet. Doxorubicin, a cytotoxic chemotherapeutic agent used to treat a variety of cancers, can cause mitochondrial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Ohwia caudata aqueous extract attenuates doxorubicin‐induced mitochondrial dysfunction in Wharton's jelly‐derived mesenchymal stem cells

Lee

Tsai

Sitorus

et al. 2023

Environmental Toxicology

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Mitochondrial dysfunction has been linked to many diseases, including organ degeneration and cancer. Wharton's jelly‐derived mesenchymal stem cells provide a valuable source for stem cell‐based therapy and represent an emerging therapeutic approach for tissue regeneration. This study focused on screening the senomorphic properties of Ohwia caudata aqueous extract as an emerging strategy for preventing or treating mitochondrial dysfunction in stem cells. Wharton's jelly‐derived mesenchymal stem cells were incubated with 0.1 μM doxorubicin, for 24 h to induce mitochondrial dysfunction. Next, the cells were treated with a series concentration of Ohwia caudata aqueous extract (25, 50, 100, and 200 μg/mL) for another 24 h. In addition, an untreated control group and a doxorubicin‐induced mitochondrial dysfunction positive control group were maintained under the same conditions. Our data showed that Ohwia caudata aqueous extract markedly suppressed doxorubicin‐induced mitochondrial dysfunction by increasing Tid1 and Tom20 expression, decreased reactive oxygen species production, and maintained mitochondrial membrane potential to promote mitochondrial stability. Ohwia caudata aqueous extract retained the stemness of Wharton's jelly‐derived mesenchymal stem cells and reduced the apoptotic rate. These results indicate that Ohwia caudata aqueous extract protects Wharton's jelly‐derived mesenchymal stem cells against doxorubicin‐induced mitochondrial dysfunction and can potentially prevent mitochondrial dysfunction in other cells. This study provides new directions for the medical application of Ohwia caudata.

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Caudatan A, an undescribed human kidney-type glutaminase inhibitor with tetracyclic flavan from Ohwia caudata

Cited by 12 publications

References 30 publications

Lignans and Flavonoids from Cajanus cajan (L.) Millsp. and Their α‐Glucosidase Inhibitory Activities

Lignans and Flavonoids from Cajanus cajan (L.) Millsp. and Their α‐Glucosidase Inhibitory Activities

Ohwia caudata aqueous extract attenuates senescence in aging adipose-derived mesenchymal stem cells

Ohwia caudata aqueous extract attenuates doxorubicin‐induced mitochondrial dysfunction in Wharton's jelly‐derived mesenchymal stem cells

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