Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

Yang, Jung-Ho; Jeong, Ji-An; Kweon, Sun-Seog; Lee, Young‐Hoon; Choi, Seong-Woo; Ryu, So Yeon; Nam, Hae-Sung; Park, Kyeong-Soo; Kim, Hye Yeon; Shin, Min Ho

doi:10.4070/kcj.2021.0269

Cited by 8 publications

(12 citation statements)

References 27 publications

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“…In addition, ALDH2 * 2/ * 2 with non-drinking was discovered to be a protective factor for AF. As supported in our study, Yamashita T et (25).…”

Section: Discussionsupporting

confidence: 89%

Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation

Han

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAcetaldehyde dehydrogenase 2 (ALDH2) is an essential enzyme in alcohol metabolism, playing a vital function in resisting oxidative stress. Lots of gene variants have been associated with atrial fibrillation (AF), among which the association between ALDH2 rs671 polymorphism and AF is variable. This study aimed to investigate the relationship between ALDH2 rs671 polymorphism and AF occurrence or progression and AF recurrence after catheter ablation.MethodsA total of 924 subjects were enrolled in the study. The ALDH2 genotypes are composed of wild-type homozygotes (ALDH2*1/*1), heterozygotes (ALDH2*1/*2), and mutant homozygotes (ALDH2*2/*2), in which the genotypes ALDH2*1/*2 and ALDH2*2/*2 are combined into the ALDH2*2. Univariate and multivariate logistic regression analyses were performed to investigate the association between ALDH2*2 and AF occurrence and progression. COX regression analysis was used to explore the association of ALDH2*2 with AF recurrence after catheter ablation.ResultsThe prevalence of AF differed significantly between the ALDH2*2 group (102/251) and ALDH2*1/*1 group (330/673) (P = 0.023). For AF occurrence, in the univariate analysis, alcohol consumption was a risk factors (OR: 1.503, P = 0.003), whereas ALDH2*2 was a protective factor (OR: 0.712, P = 0.023). In the multivariate analysis, alcohol consumption (P = 0.156) and ALDH2*2 (P = 0.096) were no longer independent factors. ALDH2*2 with non-drinking was associated with a decreased AF occurrence (OR: 0.65, P = 0.021), whereas ALDH2*2 with drinking was not (P = 0.365). For AF progression, multivariate analysis revealed ALDH2*2 could promote persistent AF in female AF patients (OR: 2.643, P = 0.008). Cox regression analysis suggested that ALDH2*2 (P = 0.752) was not a risk factor for AF recurrence after catheter ablation during a median 6 months follow-up.ConclusionWhile ALDH2*2 was not directly related to AF, ALDH2*2 with non-drinking was associated with a decreased incidence of AF. ALDH2*2 may accelerate AF progression in female patients, increasing the likelihood of developing persistent AF. Therefore, individuals with ALDH2*2 should refrain from consuming alcohol to decrease the onset and progression of AF.

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“…In addition, ALDH2 * 2/ * 2 with non-drinking was discovered to be a protective factor for AF. As supported in our study, Yamashita T et (25).…”

Section: Discussionsupporting

confidence: 89%

Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation

Han

et al. 2022

Front. Cardiovasc. Med.

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“…These participants even had a reduced risk of AF compared to wild-type non-drinkers [ 228 ]. A Korean Mendelian randomization study with 8964 participants using the ALDH2 genotypes reported a significant relationship between alcohol consumption and AF [ 229 ].…”

Section: Atrial Myocardium and Alcoholmentioning

confidence: 99%

Harmful Impact of Tobacco Smoking and Alcohol Consumption on the Atrial Myocardium

Ohlrogge

Frost

Schnabel

2022

Cells

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Tobacco smoking and alcohol consumption are widespread exposures that are legal and socially accepted in many societies. Both have been widely recognized as important risk factors for diseases in all vital organ systems including cardiovascular diseases, and with clinical manifestations that are associated with atrial dysfunction, so-called atrial cardiomyopathy, especially atrial fibrillation and stroke. The pathogenesis of atrial cardiomyopathy, atrial fibrillation, and stroke in context with smoking and alcohol consumption is complex and multifactorial, involving pathophysiological mechanisms, environmental, and societal aspects. This narrative review summarizes the current literature regarding alterations in the atrial myocardium that is associated with smoking and alcohol.

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“…They observed that genetically predicted alcohol consumption was significantly associated with AF, suggesting that alcohol may be causally associated with AF development. 6) This study also has limitations. There is the possibility of misclassification in measuring the intake of alcohol and the presence of AF.…”

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confidence: 91%

“…In this issue of Korean Circulation Journal , Yang et al 6) adds new evidence for a relationship between alcohol and AF. This makes an important contribution to understanding the impact of alcohol on the risk of AF.…”

mentioning

confidence: 99%

“…Mendelian randomization (MR) research has recently received great attention as an alternative to overcoming the limitations of observational studies in causality assessment. 7) Yang et al 6) conducted MR analysis within the Dong-gu Study, a community-based cohort study. They used alcohol dehydrogenase 2 (ALDH2) rs671 polymorphism as an instrumental variable, which affects drinking behavior but not directly on the risk of AF.…”

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confidence: 99%

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Another Reason to Cut Down on Alcohol?

Kim

2022

Korean Circ J

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Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

Cited by 8 publications

References 27 publications

Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation

Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation

Harmful Impact of Tobacco Smoking and Alcohol Consumption on the Atrial Myocardium

Another Reason to Cut Down on Alcohol?

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