2023
DOI: 10.21203/rs.3.rs-3367539/v1
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Causal Associations between Sarcopenia Traits and Cognitive Impairment: A Mendelian Randomization Study

Hengfei Zhang,
Heng Wang,
Yixu Xie
et al.

Abstract: Observational studies had indicated an association between cognitive impairment and sarcopenia, but high-quality causal effect evidence remained lacking. The purpose of this study is to determine the causal relationship between cognitive impairment and sarcopenia through a bidirectional Mendelian randomization (MR) study. The inverse variance-weighted (IVW) method was employed as the primary analytical approach to assess causal relationships. Additionally, we conducted sensitivity analyses using MR-Egger and w… Show more

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