Causal Link between Inflammatory Bowel Disease and Fistula: Evidence from Mendelian Randomization Study

Tan, Zongbiao; Zhu, Shijie; Liu, Chuan; Meng, Yang; Li, Jiao; Zhang, Jixiang; Dong, Weiguo

doi:10.3390/jcm12072482

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…To eliminate LD among the SNPs, clumping process was implemented with R2 < 0.001 and kb = 10,000. The F statistics were calculated using the formula (F = β2/SE2) for each SNP separately [ 14 , 15 ], Subsequently, we confirmed that the F statistic exceeded 10 in order to mitigate any potential effects of weak instrumental variable bias. Figure 1 depicted the study design through a study framework diagram.…”

Section: Methodsmentioning

confidence: 77%

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Li,

Wang,

Hua

et al. 2023

Discov Onc

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Objective Previous observational studies have explored the correlation between testosterone and cancer risk. However, the causal association between testosterone and various cancer types in women remains inconclusive. The objective of this Mendelian randomization study is to evaluate the causal links between total testosterone (TT) and bioavailable testosterone (BT) with cancer risk in females. Methods Initially, a rigorous quality control process was employed to identify suitable instrumental single nucleotide polymorphisms (SNPs) associated with the exposure under investigation that exhibited a significant association. The genetic causal relationship between female testosterone levels and the risk of developing cancers was examined through a two-sample Mendelian randomization. Various analytical methods, including inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode, were applied in the investigation. Key findings were primarily based on the results obtained via IVW (random effects), and sensitivity analyses were conducted to assess the reliability of the obtained results. Furthermore, maximum likelihood, penalized weighted median, and IVW (fixed effects) methods were utilized to further validate the robustness of the results. Results Based on the results of IVW analysis, our study indicated a positive causal relationship between BT and breast cancer (OR = 1.1407, 95%CI: 1.0627–1.2244, P = 0.0015) and endometrial cancer (OR = 1.4610, 95%CI: 1.2695–1.6813, P = 1.22E-06). Moreover, our findings also showed a positive causal association between TT and breast cancer (OR = 1.1764, 95%CI: 1.0846–1.2761, P = 0.0005), cervical cancer(OR = 1.0020, 95%CI: 1.0007–1.0032, P = 0.0077), and endometrial cancer(OR = 1.4124, 95%CI: 1.2083–1.6511, P = 0.0001). Additionally, our results demonstrated a negative causal relationship between BT and ovarian cancer (OR = 0.8649, 95%CI: 0.7750–0.9653, P = 0.0320). However, no causal relationship was found between BT, TT and other types of cancer (corrected P > 0.05). Conclusions This study elucidates the role of testosterone on the development of breast cancer, endometrial cancer, ovarian cancer, and cervical cancer. It also hints at a potential but fragile link between testosterone and bladder cancer, as well as thyroid cancer. Nonetheless, it's worth noting that no statistically significant relationship between testosterone and various other types of cancer in females was identified.

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Section: Methodsmentioning

confidence: 77%

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Li,

Wang,

Hua

et al. 2023

Discov Onc

View full text Add to dashboard Cite

show abstract

“…To eliminate LD between the SNPs, clumping process was implemented with R2 < 0.001 and kb = 10000. The F statistics were calculated using the formula (F = β2/SE2) for each SNP separately [11,12], Subsequently, we con rmed that the F statistic exceeded 10 in order to mitigate any potential effects of weak instrumental variable bias.…”

Section: Instrumental Variable Selectionmentioning

confidence: 99%

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Li,

Wang,

Hua

et al. 2023

Preprint

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Objective: Previous observational studies have explored the correlation between testosterone and cancer risk. However, the causal association between testosterone and various cancer types in women remains inconclusive. The objective of this Mendelian randomization study is to evaluate the causal links between total testosterone (TT) and bioavailable testosterone (BT) with cancer risk in females. Methods: Initially, a rigorous quality control process was used to identify suitable instrumental single nucleotide polymorphisms (SNPs) linked with the exposure under investigation that exhibited a significant association. The genetic causal relationship between female testosterone levels and the risk of developing cancers was examined via two-sample Mendelian randomization. A variety of analytical methods, including inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode, were employed in the investigation. Key findings were primarily based on the results obtained via IVW (random effects), and sensitivity analyses were conducted to assess the reliability of the obtained results. Moreover, maximum likelihood, penalized weighted median, and IVW (fixed effects) methods were utilized in order to further validate the robustness of the results. Results: Based on the results of IVW analysis, our study indicated a positive causal relationship between BT and breast cancer (OR = 1.1184, 95%CI: 1.0448-1.1971, P = 0.0083) and endometrial cancer (OR = 1.4995, 95%CI: 1.3179-1.7061, P = 9.94E-09). Moreover, our findings also showed a positive causal association between TT and breast cancer (OR = 1.1403, 95%CI: 1.0574-1.2298, P = 0.0043), cervical cancer (OR = 1.0017, 95%CI: 1.0006-1.0028, P =0.0122), and endometrial cancer (OR = 1.5046, 95%CI: 1.3103-1.7277, P = 9.06E-08). However, no causal relationship was found with BT and TT on other types of cancer (corrected P> 0.05). Conclusions: This study elucidates the role of testosterone in the development of breast cancer, endometrial cancer, and cervical cancer, while also indicating a potential tenuous link between testosterone and bladder cancer as well as skin cancer. Nonetheless, no statistically meaningful relationship between testosterone and various other types of cancer in females was observed.

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“…The quality of life (QoL) of individuals with immunological disorders is not only significantly impacted by physical and biomedical complications, but also by the psychological and psychosocial challenges of these conditions. Disease specific complications include joint deformities, uveitis [1], cardiovascular problems, and osteoporosis for Rheumatoid Arthritis (RA) and Spondylarthritis (SpA) [2], malnutrition [3,4], colorectal cancer [5,6], stenosis [7], and fistulas [8] for Inflammatory Bowel Disease (IBD; Cohn's disease and Ulcerative colitis) and, arthritis [9], cardiovascular diseases [10], and secondary bacterial infections for Psoriasis (PsO) and Hidradenitis Suppurativa (HS) [11]. Psychological issues are often overlapping for the disorders, such as depression, anxiety, stigmatization and social withdrawal [2,11,12] In addition to appropriate medical treatment, it is essential to consider how individuals experience their own health [13].…”

Section: Introductionmentioning

confidence: 99%

Personalizing supportive healthcare for patients with immunological disorders

Folkertsma,

Bos,

Vodegel

et al. 2024

Preprint

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Current insights to personalize supportive care for patients with immunological disorders, especially in the context of medical treatments, remain inadequate. Delivering and guiding supportive care unquestionably contributes to a higher quality of life and better overall healthcare. The 'Subjective Health Experience (SHE) Model' provides a general framework, comprising four segments, to differentiate supportive healthcare in a quick and practical approach. In this report both health care workers and patients tailored the unique needs of patients with immunological disorders to improve their supportive care. Employing qualitative methods, group discussions and individual interviews were conducted with 19 healthcare professionals and 18 patients suffering from Rheumatoid Arthritis/Spondylarthritis, Inflammatory Bowel Disease (Crohn’s disease and Ulcerative colitis), and Psoriasis/Hidradenitis Suppurativa. The aim was to ascertain nuanced insights into the behaviour, questions, and needs of patients with six common immunological conditions guided by the SHE-model, thereby refining the personalized supportive care framework. A detailed description was made for patients with immunological disorders per SHE-model segment. Based on these insights, it was determined for each segment ‘WHAT’ kind of supportive care is needed and ‘HOW’ it should be offered. Notably, patients emphasized the qualitative aspects of their interactions with healthcare professionals (attention, acknowledgment, and empathetic communication), contrasting with professionals’ focus on the treatment plan. This led to a strategic allocation of supportive care interventions across patient segments. This study has significantly advanced our understanding of appropriate supportive healthcare for patients with immunological disorders from the perspective of the SHE-model. These findings not only enrich the existing literature but also equip healthcare professionals with a concrete guide for enhancement of supportive care, as the SHE-model is easy to perform in daily clinical care. Attention, acknowledgment, and listening comprise the foundational elements for offering and guiding supportive care.

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Causal Link between Inflammatory Bowel Disease and Fistula: Evidence from Mendelian Randomization Study

Cited by 8 publications

References 45 publications

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study

Personalizing supportive healthcare for patients with immunological disorders

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