Causal relationship between cannabis use and cancer: a genetically informed perspective

Huang, Peng; Zhang, Peng Fei; Li, Qiu

doi:10.1007/s00432-023-04807-x

Cited by 13 publications

(2 citation statements)

References 56 publications

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“…IV selection criteria in this study: SNPs exhibiting a genome‐wide significant association with the BP phenotype ( p < 5E‐06) 18 Lack of linkage disequilibrium (LD) between SNPs.…”

Section: Methodsmentioning

confidence: 99%

Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study

He,

Wang,

Ran

et al. 2024

The Journal of Dermatology

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Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects the elderly. However, the relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, which included only European populations, was to assess the potential causative link between BP and 13 types of malignant tumors in a two‐sample Mendelian randomization (MR) study. BP was not associated with an increased risk of developing 13 types of malignant tumors. This study did not find a causal relationship between BP and malignant tumors. However, further research is warranted to examine the generalizability of this conclusion in non‐European populations.

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“…IV selection criteria in this study: SNPs exhibiting a genome‐wide significant association with the BP phenotype ( p < 5E‐06) 18 Lack of linkage disequilibrium (LD) between SNPs.…”

Section: Methodsmentioning

confidence: 99%

Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study

He,

Wang,

Ran

et al. 2024

The Journal of Dermatology

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“…When HCC cells were exposed to ferroptosis inducers including sorafenib, buthionine sulfoximine, and erastin, there was an upregulation of p62 [ 64 , 65 ]. Upregulated p62 exerts a regulatory crucial role by inactivating Keap1 and promoting the nuclear translocation of NRF2 [ 66 ]. Nuclear NRF2 transactivates HMOX1, NQO1, MT1G or ferritin heavy chain 1 (FTH1), which confers cellular defense mechanisms against ferroptosis [ 64 , 65 , 67 ].…”

Section: The Molecular Pathways Of Ferroptosis In Hccmentioning

confidence: 99%

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Jin,

Huang,

Tian

2024

Clin Exp Med

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Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form of regulated cell death, possesses distinct morphological, biochemical, and genetic characteristics compared to other types of cell death. Dysregulated actions within the molecular network that regulates ferroptosis have been identified as significant contributors to the progression of HCC. Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse cellular processes, regulating gene function and expression through multiple mechanistic pathways. An increasing body of evidence indicates that deregulated lncRNAs are implicated in regulating malignant events such as cell proliferation, growth, invasion, and metabolism by influencing ferroptosis in HCC. Therefore, elucidating the inherent role of ferroptosis and the modulatory functions of lncRNAs on ferroptosis in HCC might promote the development of novel therapeutic interventions for this disease. This review provides a succinct overview of the roles of ferroptosis and ferroptosis-related lncRNAs in HCC progression and treatment, aiming to drive the development of promising therapeutic targets and biomarkers for HCC patients.

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Cannabis Use and Head and Neck Cancer

Gallagher,

Chung,

Lin

et al. 2024

JAMA Otolaryngol Head Neck Surg

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ImportanceCannabis is the most commonly used illicit substance worldwide. Whether cannabis use is associated with head and neck cancer (HNC) is unclear.ObjectiveTo assess the clinical association between cannabis use and HNC.Design, Setting, and ParticipantsThis large multicenter cohort study used clinical records from a database that included 20 years of data (through April 2024) from 64 health care organizations. A database was searched for medical records for US adults with and without cannabis-related disorder who had recorded outpatient hospital clinic visits and no prior history of HNC. Propensity score matching was performed for demographic characteristics, alcohol-related disorders, and tobacco use. Subsequently, relative risks (RRs) were calculated to explore risk of HNC, including HNC subsites. This analysis was repeated among those younger than 60 years and 60 years or older.ExposureCannabis-related disorder.Main Outcomes and MeasuresDiagnosis of HNC and any HNC subsite.ResultsThe cannabis-related disorder cohort included 116 076 individuals (51 646 women [44.5%]) with a mean (SD) age of 46.4 (16.8) years. The non–cannabis-related disorder cohort included 3 985 286 individuals (2 173 684 women [54.5%]) with a mean (SD) age of 60.8 (20.6) years. The rate of new HNC diagnosis in all sites was higher in the cannabis-related disorder cohort. After matching (n = 115 865 per group), patients with cannabis-related disorder had a higher risk of any HNC (RR, 3.49; 95% CI, 2.78-4.39) than those without HNC. A site-specific analysis yielded that those with cannabis-related disorder had a higher risk of oral (RR, 2.51; 95% CI, 1.81-3.47), oropharyngeal (RR, 4.90; 95% CI, 2.99-8.02), and laryngeal (RR, 8.39; 95% CI, 4.72-14.90) cancer. Results were consistent when stratifying by older and younger age group.Conclusions and RelevanceThis cohort study highlights an association between cannabis-related disorder and the development of HNC in adult patients. Given the limitations of the database, future research should examine the mechanism of this association and analyze dose response with strong controls to further support evidence of cannabis use as a risk factor for HNCs.

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Causal relationship between cannabis use and cancer: a genetically informed perspective

Cited by 13 publications

References 56 publications

Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study

Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside

Cannabis Use and Head and Neck Cancer

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