Causal relationship between particulate matter 2.5 (PM_2.5), PM_2.5 absorbance, and COVID-19 risk: A two-sample Mendelian randomisation study

Causal relationship and shared genes between air pollutants and amyotrophic lateral sclerosis: A large‐scale genetic analysis

“…Several earlier studies employed MR to look into the connection between air pollution and different health outcomes. [19][20][21][22][23][24][25][26][27][28][29][30][31] Yi et al, for example, conducted a TSMR analysis reporting a causal link between air pollution and neurodegenerative disorders (Alzheimer's disease and Parkinson's diseases). 24 Wang et al demonstrated the causal evidence that air pollution might cause multiple cancer types by MR. 20 However, the causal relationship and underlying biological mechanisms between air pollution and ALS remains largely unexplored.…”

“…With genome‐wide association studies (GWAS) providing existing summary statistics, MR has been extensively applied across diverse research domains. Several earlier studies employed MR to look into the connection between air pollution and different health outcomes 19–31 . Yi et al., for example, conducted a TSMR analysis reporting a causal link between air pollution and neurodegenerative disorders (Alzheimer's disease and Parkinson's diseases) 24 .…”