Causal Structure of the Frohlich Model of Cellular Electromagnetic Activity

Šrobár, F.; Pokorný, Jiřı́

doi:10.3109/15368379909022582

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…Excitation depends on the amount of energy supplied to the system, but not on the manner of its supply [25]. Analysis of the feedback loops in Fröhlich's system can determine excitation as a function of the intensity of pumping which need not be a linear function [26,27]. Electron charge on delocalized orbitals may be important for the Fröhlich's mechanism.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic Field of Microtubules: Effects on Transfer of Mass Particles and Electrons

2005

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Abstract. Biological polar molecules and polymer structures with energy supply (such as microtubules in the cytoskeleton) can get excited and generate an endogenous electromagnetic field with strong electrical component in their vicinity. The endogenous electrical fields through action on charges, on dipoles and multipoles, and through polarization (causing dielectrophoretic effect) exert forces and can drive charges and particles in the cell. The transport of mass particles and electrons is analyzed as a Wiener-Lévy process with inclusion of deterministic force (validity of the Bloch theorem is assumed for transport of electrons in molecular chains too). We compare transport driven by deterministic forces (together with an inseparable thermal component) with that driven thermally and evaluate the probability to reach the target. Deterministic forces can transport particles and electrons with higher probability than forces of thermal origin only. The effect of deterministic forces on directed transport is dominant.

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Section: Introductionmentioning

confidence: 99%

Electromagnetic Field of Microtubules: Effects on Transfer of Mass Particles and Electrons

2005

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“…We have shown (Šrobár and Pokorný, 1999;Šrobár, 2005, 2009) that ensembles counting just two or three coupled oscillators (the behaviour of which can be described exactly) evince the hallmark properties of the Fröhlich systems, such as the energy condensation. Figure 2 details the scheme of Figure 1 for the case of three oscillators.…”

Section: The Phenomenon Of Energy Condensationmentioning

confidence: 84%

Fröhlich Systems in Cellular Physiology

Šrobár

2012

Prague Med. Rep.

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Electromagnetic fields are usually absent in the picture of processes taking place in living cells which is dominated by biochemistry, molecular genetics and microscopic morphology. Yet experimental and theoretical studies suggest that this omission is not justified. At the end of 1960's H. Fröhlich elaborated a semi-phenomenological model of polar oscillating units that are metabolically driven, exchange energy with the cell's internal heat reservoir, and store part of the energy in excited vibrational modes in such way, that mode with the lowest frequency becomes highly excited, while the higher-order modes remain near thermal equilibrium. This affords energy-hungry chemical reactions to take place while the rest of the cell is not exposed to heat stress. At present, part of the cytoskeleton - microtubules - are deemed to fulfil the role of oscillating units. The paper provides an introduction to the Fröhlich ideas for readers with background in medicine and biology in that it avoids mathematical formulas and relies on figures to convey information about the basic properties of the model. The essential features of the Fröhlich model - most notably the energy condensation - are demonstrated on ensemble encompassing three coupled vibration modes that can be exactly described using original diagrammatic method.

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“…Feedback mechanisms operate also on the level of intracellular generators of electromagnetic radiation [9,10]. This activity is supported by the polar molecular structures within the cell (like microtubule filaments) or the cell membrane and is driven by the cell's energy sources (GTP or ATP hydrolysis).…”

Section: Numerical Results and Discussionmentioning

confidence: 99%

Feedback loops in the signal paths controlling gene expression

Šrobár

2004

Bioelectrochemistry

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Causal Structure of the Frohlich Model of Cellular Electromagnetic Activity

Cited by 7 publications

References 5 publications

Electromagnetic Field of Microtubules: Effects on Transfer of Mass Particles and Electrons

Electromagnetic Field of Microtubules: Effects on Transfer of Mass Particles and Electrons

Fröhlich Systems in Cellular Physiology

Feedback loops in the signal paths controlling gene expression

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