Causality between alcohol usually taken with meals and Meniere disease: A 2-sample Mendelian randomization study

Abstract

The recurrence of Meniere disease (MD) strongly affects patient quality of life. Identifying the risk factors for MD is highly important for its prevention and treatment. Previous studies have suggested that alcohol intake may play a role in the development of MD. However, recent studies have shown that the causal relationship between alcohol consumption and MD remains controversial. In this paper, the Mendelian randomization (MR) method was used to determine the causal relationship between alcohol consumption usually consumed with meals and MD, with the aim of providing suggestions for alcohol intake management in individuals with MD and helping in the prevention and treatment of MD. Two-sample MR was used to investigate the causal relationship between alcohol usually taken with meals and MD. We used a dataset from a publicly available large-scale genome-wide association study (GWAS). Inverse variance weighting (IVW), MR–Egger, simple weighting, weighted weighting and the weighted median method were used for analysis. The final results showed that IVW (OR = 0.991, 95% CI: 0.983–0.998, P = .016) results suggested that there was statistical significance, but MR–Egger (OR = 0.978, 95% CI: 0.886–1.080, P = .679), weighted median methods (OR = 0.994, 95% CI: 0.985–1.004, P = .307) and Simple mode (OR = 0.995, 95% CI: 0.980–1.010, P = .566), Weighted mode (OR = 0.995, 95% CI: 0.981–1.010, P = .557) found no significant causal relationship. The results suggest that alcohol usually taken with meals may be negatively correlated with MD.