Causality of genetically determined metabolites and metabolic pathways on joint diseases: a two-sample mendelian randomization study
Binbin Zhang,
Chuan Lu,
Bin Dou
et al.
Abstract:OBJECTIVE: Infectious arthropathies, inflammatory polyarthropathy, osteoarthropathies, and many other joint diseases are now prevalent worldwide. A large number of studies have suggested an association between metabolites and joint diseases, but due to the limitations of routine observational studies, its significance is not clear. In this paper, we used Mendelian randomization to assess potential causal associations between metabolites and a variety of joint diseases.
METHODS: By screening publicly available … Show more
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