2016
DOI: 10.2147/ijn.s115158
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Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells

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Cited by 23 publications
(16 citation statements)
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“…In our present study, we demonstrated that the loss of Cav-1 protein was attributed to PA-induced autophagic degradation, but not proteasomal degradation. Although the regulation of autophagy by Cav-1 has been reported in several cell models 46 , 49 , we showed that neither Cav-1 overexpression nor Cav-1 knockdown does affect the autophagy process in PA-treated hippocampal astrocytes. Recently, it has been reported that, in primary astrocytes derived from prnp +/+ or prnp 0/0 mice, suppressed autophagy was due to the higher levels of Cav-1 in lipid raft, but not the total levels of Cav-1 50 .…”
Section: Discussioncontrasting
confidence: 69%
“…In our present study, we demonstrated that the loss of Cav-1 protein was attributed to PA-induced autophagic degradation, but not proteasomal degradation. Although the regulation of autophagy by Cav-1 has been reported in several cell models 46 , 49 , we showed that neither Cav-1 overexpression nor Cav-1 knockdown does affect the autophagy process in PA-treated hippocampal astrocytes. Recently, it has been reported that, in primary astrocytes derived from prnp +/+ or prnp 0/0 mice, suppressed autophagy was due to the higher levels of Cav-1 in lipid raft, but not the total levels of Cav-1 50 .…”
Section: Discussioncontrasting
confidence: 69%
“…Our study focused on phosphorylated S2448 mTOR (p-mTOR), as this is the phosphorylation site that has been shown to activate proteins downstream of mTOR such as RS6K1 [40, 73, 74]. The specificity of the chosen antibody has been demonstrated by western blot [75, 76]. This antibody has also been used by others to quantify p-mTOR in brain [77, 78], including after treadmill training [62].…”
Section: Methodsmentioning
confidence: 99%
“…Chronic myelogenous leukemia (CML), also called chronic myeloid leukemia, is a cancer involving the bone marrow hematopoietic stem cells. It accounts for approximately 15% of adult leukemia (Shi et al 2016 ). The typical properties of this disease are the chromosomal translocation and increased and unregulated growth of predominantly myeloid cells in the bone marrow, as well as the accumulation of these cells in the blood and spleen (Fu et al 2016 ).…”
Section: Introductionmentioning
confidence: 99%