2023
DOI: 10.1016/j.bbi.2023.02.001
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CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice

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Cited by 39 publications
(23 citation statements)
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“…The percentage of CD68‐positive area in IBA1‐positive cells in the mPFC was significantly higher in alcohol‐treated mice than in control mice, and this percentage was further increased in the alcohol group cotreated with DMXAA (Figure 5I,J). Changes in the morphology of microglia indicate alterations in their function 33 . Microglia typically exhibit a ramified morphology, but upon activation, they display a deramified or amoeboid morphology.…”
Section: Resultsmentioning
confidence: 99%
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“…The percentage of CD68‐positive area in IBA1‐positive cells in the mPFC was significantly higher in alcohol‐treated mice than in control mice, and this percentage was further increased in the alcohol group cotreated with DMXAA (Figure 5I,J). Changes in the morphology of microglia indicate alterations in their function 33 . Microglia typically exhibit a ramified morphology, but upon activation, they display a deramified or amoeboid morphology.…”
Section: Resultsmentioning
confidence: 99%
“…Male C57BL/6 mice, aged six to eight weeks and weighing 18–22 g, were obtained from Zhuhai BesTest Bio‐Tech Co., Ltd. All animal experiments were approved by the Animal Ethical and Welfare Committee of Sun Yat‐Sen Memorial Hospital, Sun Yat‐sen University. A chronic alcohol exposure model was constructed based on our previous studies with a slight modification 32,33 . In experiment 1, mice were randomly divided into three groups: the Sham group, EtOH group (25% ethanol w/v, administered i.g., 28 d, 5 g/kg/day), and EtOH + DMXAA (intraperitoneal injection, 25 mg/kg, S1537, Selleck) group.…”
Section: Methodsmentioning
confidence: 99%
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“…CB 2 receptors are found in pyramidal neurons in layers III and V of cerebral cortex (Onaivi, 2006), although their abundance and distribution in the mPFC has not been specified, nor has their presence on GABAergic neurons in the mPFC been investigated. Functionally, CB 2 receptor activation ameliorated anxiety-like behaviors on the elevated plus maze in mice that underwent chronic alcohol exposure (four weeks of daily 4 g/kg alcohol via oral gavage; Li et al, 2023).…”
Section: Discussionmentioning
confidence: 99%