CCAAT enhancer-binding proteins have long boney fingers

Luft, Friedrich C.

doi:10.1007/s00109-011-0838-z

Cited by 3 publications

(2 citation statements)

References 15 publications

(15 reference statements)

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“…Hydrogen sulfide (H 2 S) has been referred to as the third gasotransmitter in animal and plant cells and is as important as nitric oxide (NO), carbon monoxide (CO), and hydrogen peroxide (H 2 O 2 ) ( García-Mata and Lamattina, 2010 ; Vandiver and Snyder, 2012 ; Kimura, 2014 ). These small molecules possess high permeability that allows them to cross biological membranes and to act as signaling molecules.…”

Section: Introductionmentioning

confidence: 99%

Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis

Aroca

Benito

Gotor

et al. 2017

Journal of Experimental Botany

259

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Section: Introductionmentioning

confidence: 99%

Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis

Aroca

Benito

Gotor

et al. 2017

Journal of Experimental Botany

259

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“…A possible explanation of the central role of inflammation can be related to the inflammatory microenvironment that releases IL-6, whose levels are linked to poor prognosis, disease progression, residual disease after debulking surgery, ascites or anemia [23, 24]. Indeed IL-6 seems to play a key role in determining platinum-resistance inducing HIF-1 and STAT-3 expression/activity that promotes VEGF overexpression [25, 26]. In turn VEGF supports ascites production, by increasing peritoneal permeability and immune suppression, by impairing dendritic cells maturation and Th1 response [27].…”

Section: Introductionmentioning

confidence: 99%

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation

et al. 2016

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ObjectivesThe current gold-standard for the first-line treatment in IIIb/IV stages of epithelial ovarian cancer (EOC) is the combination of carboplatin and paclitaxel plus bevacizumab in some countries. In the era of personalized medicine, there is still uncertainty on the impact of several molecularly targeted agents, which have been investigated for the management of this disease. To shed light on the actual role of targeted therapy in EOC, a systematic review and meta-analysis was performed.MethodsClinical trials were selected by searching “Pubmed” database and abstracts from major cancer meetings within the time-frame of January 2004-June 2015. The endpoints were survival outcome and response rate (RR). Hazard ratios (HRs) of survival outcomes, with confidence intervals and odds-ratios (ORs) of RR, were extracted from retrieved studies and used for current analysis. Meta-analysis was carried out by random effect model.Results30 randomized trials for a total of 10,530 patients were selected and included in the final analysis. A benefit in terms of OS (pooled HR 0.915; 95%CI 0.840-0.997; p=0.043), particularly for anti-angiogenetic agents (HR 0.872; 95%CI 0.761-1.000; p=0.049), has been demonstrated for targeted therapy. Moreover, a significant advantage in platinum-resistant subgroup in term of PFS (HR 0.755; 95%CI 0.624-0.912; p=0.004) was found.ConclusionsThis systematic review and meta-analysis provide the first evidence that targeted therapy is potentially able to translate into improved survival of EOC patients, with a major role played by anti-angiogenetic drugs. The role of target therapy is underlined in the platinum-resistant setting that represents the “pain in the neck” in EOC management.

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Everolimus restrains the IL-17A-dependent osteoclast-like transdifferentiation of dendritic cells in multiple myeloma

Tucci

Stucci

Passarelli

et al. 2017

Experimental Hematology

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CCAAT enhancer-binding proteins have long boney fingers

Cited by 3 publications

References 15 publications

Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis

Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation

Everolimus restrains the IL-17A-dependent osteoclast-like transdifferentiation of dendritic cells in multiple myeloma

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