CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest

Huang, Jing; Zhang, Li; Liu, Wei; Liao, Qinyuan; Shi, Taiping; Xiao, Lin; Hu, Fanlei; Qiu, Xiaoyan

doi:10.1007/s00418-012-0932-5

Cited by 21 publications

(22 citation statements)

References 35 publications

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“… [ 58 ] 12 LIMA1 0 2 Inhibits actin depolymerization and cross-links filaments in bundles. Putative suppressor of epithelial-mesenchymal transition and metastasis [ 40 ] 17 TADA2A 0 2 transcriptional activator adaptor, in the PCAF and ATAC histone acetylase complexes, mediates DNA damage-induced apoptosis and G1/S arrest [ 44 ] 5 HSPA4 0 3 Heat shock chaperone of the HSP110 family. Regulates cell proliferation and G1/S progression by releasing transcription factor ZONAB from tight junction sequestration [ 59 ] 15 RTF1 0 3 part of the Paf1/RNA polymerase II complex, key regulator of transcription-related processes and cell-cycle progression [ 34 ] *These genes were found altered in the opposite way in the tumor H4, the only recurrent tumor in our cohort.…”

Section: Resultsmentioning

confidence: 99%

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Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

et al. 2015

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BackgroundOvarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to a C134W substitution in the transcription factor FOXL2 appears in more than 95% of adult-type GCTs. Its pervasive presence suggests that FOXL2 is the main cancer driver gene. However, other mutations and genomic changes might also contribute to tumor formation and/or progression.MethodsWe have performed a combined comparative genomic hybridization and transcriptomic analyses of 10 adult-type GCTs to obtain a picture of the genomic landscape of this cancer type and to identify new candidate co-driver genes.ResultsOur results, along with a review of previous molecular studies, show the existence of highly recurrent chromosomal imbalances (especially, trisomy 14 and monosomy 22) and preferential co-occurrences (i.e. trisomy 14/monosomy 22 and trisomy 7/monosomy 16q). In-depth analyses showed the presence of recurrently broken, amplified/duplicated or deleted genes. Many of these genes, such as AKT1, RUNX1 and LIMA1, are known to be involved in cancer and related processes. Further genomic explorations suggest that they are functionally related.ConclusionsOur combined analysis identifies potential candidate genes, whose alterations might contribute to adult-type GCT formation/progression together with the recurrent FOXL2 somatic mutation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1283-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…TADA2A-containing PCAF complex is essential for DNA-damage-induced acetylation of p53, necessary to promote cell cycle arrest and cell survival after DNA damage [ 42 , 43 ]. Moreover, TADA2A overexpression is pro-apoptotic in response to DNA damage [ 44 ]. Thus, its deletion in GCTs should provide resistance to apoptosis [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

et al. 2015

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“…We previously identified that CCDC134 could inhibit MAPK-mediated ELK1 transcriptional activity in HeLa cells (29). CCDC134 also serve as a regulator of hADA2a (human alteration/deficiency in activation 2a) in acetyltransferase activity, DNA damage-induced apoptosis, and cell-cycle arrest (33). Recently, it was found that CCDC134 inhibit the migration and invasion of tumor cells via the MAPK pathway (34).…”

Section: Discussionmentioning

confidence: 99%

Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy

et al. 2014

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CCDC134 is a poorly characterized secreted protein that may act as an immune cytokine. Here, we show that CCDC134 is differentially expressed on resting and activated immune cells and that it promotes CD8 þ T-cell activation, proliferation, and cytotoxicity by augmenting expression of the T-cell effector molecules IFNg, TNFa, granzyme B, and perforin. CCDC134 facilitated infiltration of CD8 þ T cells with enhanced cytolytic activity into tumors, demonstrating strong antitumor effects in a CD8 þ T-cell-dependent manner. Mechanistically, in CD8 þ T cells, exposure to CCDC134 promoted cell proliferation through the JAK3-STAT5 pathway, a classic feature of many cytokines of the common g-chain (g c ) cytokine receptor family. Overall, our results provide evidence that CCDC134 may serve as a member of the g c cytokine family and illustrate its potent antitumor effects by augmenting CD8 þ T-cell-mediated immunity. Cancer Res; 74(20); 5734-45. Ó2014 AACR.

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“…We also found that skin CKLF1 protein and mRNA levels were significantly elevated in AD patients than that in the normal controls. Immunohistochemical staining results indicated that CKLF1 in cytoplasma and nuclei38 was distributed on the keratinocytes of granular layer and basal layer of skin from AD patients as well as in normal controls. However, the skin lesions in AD patients showed more staining positive and intense cells in the epidermal than that in normal skin.…”

Section: Discussionmentioning

confidence: 98%

Chemokine-Like Factor 1 (CLFK1) Is Over-Expressed in Patients with Atopic Dermatitis

Yang¹,

Chen²,

Sun³

et al. 2013

Int. J. Biol. Sci.

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Background: Human chemokine-like factor 1 (CKLF1), a recently discovered chemokine, has a broad spectrum of biological functions in immune-mediated diseases. It is highly expressed on Th2 lymphocytes and is a functional ligand for human CCR4. CKLF1 has a major role in the recruitment and activation of leucocytes, which plays an important role in the pathogenesis of allergic diseases. The present study was designed to determine the expression of CKLF1 in skin and serum in patients with atopic dermatitis (AD).Methods: The CKLF1 protein expression in skin lesion was analyzed by immunohistochemistry and ELISA. The mRNA expression of CKLF1 in skin lesion was detected by Real-time PCR. The serum levels of CKLF1, IgE, eotaxin, IL-4, IL-5, and IL-13 were measured by ELISA.Results: Histopathological changes in the skin of AD patients showed local inflammation with epidermal thickening and significant inflammatory cellular infiltration. Immunohistochemistry results demonstrated that CKLF1-staining positive cells were located in the epidermal and dermis, and that the CKLF1 expression in AD patients was significantly higher than that in normal control. The CKLF1 mRNA expression in AD patients was significantly higher than that in healthy controls. Serum CKLF1 and IgE levels were significantly increased in AD patients, as were the serum levels of IL-4, IL-5, IL-13 and eotaxin.Conclusions: Both CKLF1 protien and mRNA levels are overexpressed in the skin lesion of AD patients, along with an increase in serum CKLF1 level, indicating that CKLF1 may play an important role in the development of atopic dermatitis.

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CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest

Cited by 21 publications

References 35 publications

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy

Chemokine-Like Factor 1 (CLFK1) Is Over-Expressed in Patients with Atopic Dermatitis

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