CCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health

Elnabawi, Youssef; Garshick, Michael; Tawil, Michael; Barrett, Tessa J.; Fisher, Edward A.; Sicco, Kristen Lo; Neimann, Andrea L.; Scher, Jose U.; Krueger, James G.

doi:10.1016/j.jaad.2020.10.094

Cited by 38 publications

(31 citation statements)

References 27 publications

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“…Some researchers believed that CCL20 is a mediator highly sensitive to the inflammatory response, and it could influence the endothelial cell migration [28]. Elnabawi et al pointed that CCL20 was a potential biomarker of inflammation and impaired vascular health [29]. Regrettably, we found that the expression of CCL20 did not change with or without quercetin, indicating quercetin had no significant effect on CCL20 and lymphocyte chemotaxis.…”

Section: Quercetin Inhibited the Abnormal Gsv Intimacontrasting

confidence: 49%

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

Bai

Chen

Zhu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. The patency and quality of transplanted great saphenous vein (GSV) can seriously influence the physical state and life quality of patients who accepted the coronary artery bypass grafting (CABG). Quercetin is known for antioxidant, antithrombotic, anti-inflammatory, and antitumor properties. In this study, we examined the protection of quercetin to the great saphenous vein from oxidative and inflammatory damage. Methods. The GSVs were collected from 15 patients undergoing CABG and cultured. Treated the veins by H2O2 and detected the NO, SOD, and MDA content by the relevant kits to explore the quercetin protection against oxidative damage. Then, for another group of GSVs, sheared them and detected the inflammatory cytokines, such as IL-6, TNFα, CCL20, PCNA, and VEGF. Collect the veins for H&E staining and PCNA and VEGF immunofluorescent staining. Results. Pretreatment by quercetin reduced the production of NO and MDA induced by H2O2, and increased SOD activity. Quercetin also supressed the mRNA expressions of IL-6, TNFα after mechanical damage and had no influence on CCL20 and VEGF. Consistent with the lower expression of PCNA treated by quercetin, the vein intima was thinner. Conclusion. These results demonstrated that quercetin protects GSVs by reducing the oxidative damage and inflammatory response and also suppresses the abnormal thickening of venous endothelium by inhibiting cell proliferation. It reminded that, to some extent, quercetin has the potential to release the great saphenous vein graft damage.

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Section: Quercetin Inhibited the Abnormal Gsv Intimacontrasting

confidence: 49%

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

Bai

Chen

Zhu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Chemokine CCL20 is considered a potential biomarker for disease severity, systemic inflammation, and vascular endothelial inflammation. 27 Since all T17 cells express CCR6, it is thus hypothesized that T17 cells may play a critical role in psoriasis pathogenesis and recurrence. Both innate γδ T cells and adaptive T cells are able to secrete IL-17.…”

Section: Discussionmentioning

confidence: 99%

Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis

et al. 2022

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“…In a psoriasis mouse model, γδT cells in the skin migrate to the draining lymph nodes and re-appear when the skin is exposed to imiquimod (IMQ) again. The migration relies on the CCR6-CCL20 pathway, meanwhile CCL20 is found upregulated in hypertension damaged vessel walls and the plaque of atherosclerosis [ 84 ]. This suggests the migration of γδT cells may contribute to psoriatic cardiovascular disease, pointing out the potential reason of “psoriatic march” [ 83 ].…”

Section: Immune Function Of Skinmentioning

confidence: 99%

The Trinity of Skin: Skin Homeostasis as a Neuro–Endocrine–Immune Organ

Jin

Luo

Zheng

2022

Life

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For a long time, skin was thought to be no more than the barrier of our body. However, in the last few decades, studies into the idea of skin as an independent functional organ have gradually deepened our understanding of skin and its functions. In this review, we gathered evidence that presented skin as a “trinity” of neuro–endocrine–immune function. From a neuro perspective, skin communicates through nerves and receptors, releasing neurotrophins and neuropeptides; from an endocrine perspective, skin is able to receive and secrete most hormones and has the cutaneous equivalent of the hypothalamic-pituitary-adrenal (HPA) axis; from an immune perspective, skin is protected not only by its physical barrier, but also immune cells and molecules, which can also cause inflammation. Together as an organ, skin works bidirectionally by operating peripheral neuro–endocrine–immune function and being regulated by the central nervous system, endocrine system and immune system at the same time, maintaining homeostasis. Additionally, to further explain the “trinity” of cutaneous neuro–endocrine–immune function and how it works in disease pathophysiology, a disease model of rosacea is presented.

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CCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health

Cited by 38 publications

References 27 publications

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis

The Trinity of Skin: Skin Homeostasis as a Neuro–Endocrine–Immune Organ

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