CCL5 protein level: influence on breast cancer staging and lymph nodes commitment

Derossi, Daniela Rudgeri; Amarante, Marla Karine; Guembarovski, Roberta Losi; Oliveira, Carlos Eduardo Coral de; Suzuki, Karen M.; Watanabe, Maria Angélica Ehara; Cólus, Ilce Mara de Syllos

doi:10.1007/s11033-019-05051-8

Cited by 16 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No association was found between CCR5D32 and the features analyzed (189). In accordance, Derossi et al (190) did not found an association between the CCR5D32 and CCL5 levels in breast cancer (190).…”

Section: Ccr5d32 In Cancermentioning

confidence: 71%

“…The migration of regulatory immune cells to tumor sites can create an immunosuppressor environment proper for cancer development. Also, cancer cells can subvert the anti-tumor action of chemokine-ligand interactions (187)(188)(189)(190)(191). Of note, CD4+ T cells are important modulators of the immune response, acting as drivers for the action of effector cells.…”

Section: Ccr5d32 In Cancermentioning

confidence: 99%

See 1 more Smart Citation

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Kulmann-Leal

Ellwanger

2021

Front. Immunol.

View full text Add to dashboard Cite

The genetic background of Brazilians encompasses Amerindian, African, and European components as a result of the colonization of an already Amerindian inhabited region by Europeans, associated to a massive influx of Africans. Other migratory flows introduced into the Brazilian population genetic components from Asia and the Middle East. Currently, Brazil has a highly admixed population and, therefore, the study of genetic factors in the context of health or disease in Brazil is a challenging and remarkably interesting subject. This phenomenon is exemplified by the genetic variant CCR5Δ32, a 32 base-pair deletion in the CCR5 gene. CCR5Δ32 originated in Europe, but the time of origin as well as the selective pressures that allowed the maintenance of this variant and the establishment of its current frequencies in the different human populations is still a field of debates. Due to its origin, the CCR5Δ32 allele frequency is high in European-derived populations (~10%) and low in Asian and African native human populations. In Brazil, the CCR5Δ32 allele frequency is intermediate (4-6%) and varies on the Brazilian States, depending on the migratory history of each region. CCR5 is a protein that regulates the activity of several immune cells, also acting as the main HIV-1 co-receptor. The CCR5 expression is influenced by CCR5Δ32 genotypes. No CCR5 expression is observed in CCR5Δ32 homozygous individuals. Thus, the CCR5Δ32 has particular effects on different diseases. At the population level, the effect that CCR5Δ32 has on European populations may be different than that observed in highly admixed populations. Besides less evident due to its low frequency in admixed groups, the effect of the CCR5Δ32 variant may be affected by other genetic traits. Understanding the effects of CCR5Δ32 on Brazilians is essential to predict the potential use of pharmacological CCR5 modulators in Brazil. Therefore, this study reviews the impacts of the CCR5Δ32 on the Brazilian population, considering infectious diseases, inflammatory conditions, and cancer. Finally, this article provides a general discussion concerning the impacts of a European-derived variant, the CCR5Δ32, on a highly admixed population.

show abstract

Section: Ccr5d32 In Cancermentioning

confidence: 71%

Section: Ccr5d32 In Cancermentioning

confidence: 99%

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Kulmann-Leal

Ellwanger

2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…However, the role of HBB in prostate cancer has not been reported yet. CCL5 has been reported extensively in many kinds of cancer by previous studies, like breast cancer [22][23][24], non-small-cell lung cancer [25,26], colorectal cancer [27,28]. Nevertheless, the mechanism of CCL5 in prostate cancer has not been studied very well.…”

Section: Discussionmentioning

confidence: 99%

Identification of marker genes and cell subtypes in castration-resistant prostate cancer cells

Lin¹,

Lin²,

Lin³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

The diverse tumor cell populations may be the critical roles in relapse and resistance to treatment in prostate cancer patients. This study aimed to identify new marker genes and cell subtypes among castration-resistant prostate cancer (CRPC) cells. We downloaded single-cell RNA seq profiles (GSE67980) from the Gene Expression Omnibus (GEO) database. Principal component (PC) analysis and t-Distributed Stochastic Neighbor Embedding (TSNE) analysis were performed to identify marker genes. CRPC cells were clustered and annotated. GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses among marker genes were performed. A total of 1500 genes with larger standardized variance were obtained. The top 20 genes were demonstrated in each identified 20 PCs. PC with P-value < 0.05 was selected, including PC1, PC7, PC8, and PC14. The TSNE analysis classified cells as two clusters. The top 6 genes in cluster 0 included HBB, CCL5, SLITRK4, GZMB, BBIP1, and PF4V1. Plus, the top 6 genes in cluster 1 included MLEC, CCT8, CCT3, EPCAM, TMPRSS2, EIF4G2. The GO analysis revealed that these marker genes were mainly enriched in RNA catabolic process, translational initiation, mitochondrial inner membrane, cytosolic part, ribosome, cell adhesion molecule binding, cadherin binding, and structural constituent of ribosome. The KEGG analysis showed that these marker genes mainly enriched in metabolism associated pathways, including carbon metabolism, cysteine and methionine metabolism, propanoate metabolism, pyruvate metabolism, and citrate cycle pathways. To conclude, our results provide essential insights into the spectrum of cellular heterogeneity within human CRPC cells. These marker genes, GO terms and pathways may be critical in the development and progression of human CRPC.

show abstract

“…Song et al discovered that increased secretion of CCL-5 by adipocytes enhanced the EMT effect of MDA-MB-231 and MDA-MB-453 TNBC cell lines, thereby promoting tumor growth and metastasis [ 104 ]. A significant difference in CCL-5 expression in breast tumors between stage I and stage III patients was discovered by Derossi et al [ 150 ], suggesting a possible role for CCL-5 in the aggressiveness of the tumor. In addition, overexpression of CCL-5 in HER2-positive breast cancer is associated with poor disease-free survival and lower overall survival [ 151 ].…”

Section: Breast Cancer Progression and Local Obesity-associated Biomarkersmentioning

confidence: 98%

Local Biomarkers Involved in the Interplay between Obesity and Breast Cancer

Holm

Rosendahl

Borgquist

2021

Cancers

View full text Add to dashboard Cite

Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non-melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abundant in the breast. Therefore, breast cancer develops in an adipose-rich environment. During obesity, changes in the local environment in the breast occur which are associated with breast cancer. A shift towards a pro-inflammatory state is seen, resulting in altered levels of cytokines and immune cells. Levels of adipokines, such as leptin, adiponectin, and resistin, are changed. Aromatase activity rises, resulting in higher levels of potent estrogen in the breast. Lastly, remodeling of the extracellular matrix takes place. In this review, we address the current knowledge on the changes in the breast adipose tissue in obesity associated with breast cancer initiation and progression. We aim to identify obesity-associated biomarkers in the breast involved in the interplay between obesity and breast cancer. Hereby, we can improve identification of women with obesity with an increased risk of breast cancer and an impaired prognosis. Studies investigating mammary adipocytes and breast adipose tissue in women with obesity versus women without obesity are, however, sparse and further research is needed.

show abstract

CCL5 protein level: influence on breast cancer staging and lymph nodes commitment

Cited by 16 publications

References 35 publications

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Identification of marker genes and cell subtypes in castration-resistant prostate cancer cells

Local Biomarkers Involved in the Interplay between Obesity and Breast Cancer

Contact Info

Product

Resources

About