CCL5/RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction

Tereshchenko, I. P.; Petrkova, Jana; Воевода, М. И.; Táborský, Miloš; Navratilova, Zdenka; Romaschenko, A. G.; Maksimov, V. N.; Mrázek, František; Petřek, Martin

doi:10.1155/2011/525691

Cited by 18 publications

(18 citation statements)

References 18 publications

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“…However, an observational study in Korea have inconsistently shown a decreased risk of CAD in individuals with G-403A polymorphism [11]. Still other studies could not draw any firm conclusion about the existence of association between G-403A polymorphism and CAD because of the limitation in sample size [12]–[14]. We therefore performed a meta analysis of available studies with a case-control or cohort design to clarify the role of the G-403A polymorphism in RANTES gene in development of CAD.…”

Section: Introductionmentioning

confidence: 99%

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Jia

et al. 2012

PLoS ONE

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ObjectiveThe G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and inconclusive results. In order to shed some light on these inconsistent findings, a meta analysis was performed to clarify the role of G-403A polymorphism of RANTES gene in the susceptibility of CAD.MethodsA systemic literature search of PubMed and EMBASE was conducted from their inception to March 23, 2012, to retrieve related studies. In addition, Conference Proceedings Citation Index-Science was searched, authors of relevant studies were contacted, and reference lists of the included studies and their related citations in PubMed were reviewed for additional pertinent studies.ResultsA total of 8 eligible studies were identified, with a total of 4252 CAD cases and 2150 controls. There was no evidence of significant association between G-403A polymorphism and CAD risk in any genetic model or pairwise comparisons (additive model: OR = 1.046, 95% CI = 0.883–1.239, I2 = 65.9%; recessive model: OR = 1.140, 95% CI = 0.774–1.678, I2 = 53.1%; dominant model: OR = 1.000, 95% CI = 0.820–1.21), I2 = 62.6%; AA vs GG: OR = 1.141, 95% CI = 0.734–1.773, I2 = 61.2%; GA vs GG: OR = 0.993, 95% CI = 0.800–1.232, I2 = 64.6%). Subgroup analysis and meta regression indicated that ethnicity and genotyping method accounted for the significant heterogeneity among studies. In the stratified analysis by ethnic group, G-403A polymorphism was found to be associated with increased CAD risk in Caucasian population whereas its protective role was observed in Asian population in some but not all comparisons.ConclusionData from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism and the development of CAD, and large sample size study employing unified genotyping method is needed to further evaluate the influence of G-403A polymorphism on susceptibility of CAD.

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Section: Introductionmentioning

confidence: 99%

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Jia

et al. 2012

PLoS ONE

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“…By contrast, Jang et al (2007) have suggested that the -403A allele was associated with lower serum RANTES concentration and described the significant protective effect of the polymorphism on CAD risk in Korean male patients with or without type 2 diabetes (Jang et al, 2007). Most of the studies in this meta-analysis showed no relationship between the polymorphism and CAD risk (Szalai et al, 2001;Park et al, 2007;Vogiatzi et al, 2009;Shi Ying et al, 2010;Tavakkoly-Bazzaz, et al, 2011;Tereshchenko et al, 2011).…”

Section: Discussionmentioning

confidence: 77%

Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis

Cui¹,

Ge²,

L³

2013

Genet. Mol. Res.

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ABSTRACT. The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association of the G403A polymorphism in the RANTES gene with the risk of CAD. A comprehensive search was conducted to identify all studies published on the association of the RANTES gene G403A polymorphism with CAD risk. The fixed or random-effect pooled measure was adopted based on a heterogeneity test among studies, which was evaluated using I 2 . Potential sources of between-study heterogeneity were explored using meta-regression analysis. Publication bias was estimated with Begg's rank correlation method. Eight articles were included in this meta-analysis, with 4601 CAD cases and 2522 controls. No significant association of RANTES gene G403A polymorphism with CAD was identified in any of the codominant, dominant, recessive, homozygote, or heterozygote inheritance models. No evidence of publication bias 3913 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (3): 3912-3918 (2013) RANTES gene polymorphism and coronary artery disease was detected. The meta-analysis suggested that the A allele of the G403A polymorphism in the RANTES gene has no effect on the risk of CAD. This relationship needs to be confirmed by further studies.

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“…However in another study in Korean male population RANTES −403 A allele was associated with reduced risk of CAD but they did not find such association in patients taking lipid-lowering medicine (Jang et al, 2007). A more recent study in Slavonic patients also found no association between RANTES −403 polymorphism and MI (Tereshchenko et al, 2011).…”

Section: Discussionmentioning

confidence: 86%

RANTES gene mRNA expression and its −403 G/A promoter polymorphism in coronary artery disease

Bazzaz

Amiri

Tajmir-Riahi

et al. 2011

Gene

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CCL5/RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction

Cited by 18 publications

References 18 publications

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis

RANTES gene mRNA expression and its −403 G/A promoter polymorphism in coronary artery disease

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