CCR2 Defines a Distinct Population of NK Cells and Mediates Their Migration during Influenza Virus Infection in Mice

Helden, Mary J. G. van; Zaiss, Dietmar M.; Sijts, Alice J.A.M.

doi:10.1371/journal.pone.0052027

Cited by 55 publications

(46 citation statements)

References 39 publications

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“…[19][20][21] Furthermore, CCR2 is also expressed on endothelial cells during inflammation, consistent with a potential role in wound repair. 22 Information regarding the expression of CCR2 on non-hematopoietic cells in the CNS is currently limited and inconsistent.…”

Section: Expression Of Ccr2mentioning

confidence: 70%

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

Chu

Arumugam

Gelderblom

et al. 2014

J Cereb Blood Flow Metab

137

106

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CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.

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Section: Expression Of Ccr2mentioning

confidence: 70%

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

Chu

Arumugam

Gelderblom

et al. 2014

J Cereb Blood Flow Metab

137

106

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show abstract

“…Previous studies demonstrate CCR2-dependent NK cell migration during IAV infection (35). Thus, we next assessed the changes in the mRNA levels of MCP-1 (Table I), a CCR2 ligand, at early times postinfection.…”

Section: Recruitment But Not Proliferation Resulted In Early Nk Celmentioning

confidence: 99%

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

Zhou

Wang

et al. 2016

The Journal of Immunology

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It is generally unclear what roles NK cells play during influenza virus infection with regard to different host genetic backgrounds. In this study, we show that in six inbred mouse strains, NK cells play an important protective role only in 129 mice during high-dose influenza A H1N1 virus infection. Swift and strong NK cell responses efficiently control early pulmonary viral replication in 129 mice, providing survival privilege. In addition, we identified that early activation of TLRs and RIG-I signaling in 129 mice resulted in quick production of type 1 IFNs and inflammatory cytokines, which are important reasons for the swift kinetics of NK cell responses post influenza virus infection. Thus, under different microenvironments, NK cells play differential roles against viral infections. The kinetics and magnitude of NK cell responses correlate with the distinct roles that NK cells play against influenza virus infections. Thus, our works further our understandings about the complex role of NK cells during influenza virus infection.

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“…Additionally, animal models of herpes simplex virus, influenza, and simian immunodeficiency virus infection also revealed the existence of memory NK cells. In these studies, NK cells previously exposed to viral antigens conferred enhanced IFN-γ production, cytotoxicity, and protection upon re-challenge [9], [22]–[24], [25*], [26]. The ligand and NK cell receptor(s) responsible for protection against these viruses (other than MCMV) are unknown and identifying them will give scientists insight into controlling these viral infections in humans.…”

Section: Nk Cell Memorymentioning

confidence: 99%

NK cells in host responses to viral infections

Lam

Lanier

2017

Current Opinion in Immunology

123

106

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Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in viral clearance. NK cell responses to viral infections were originally believed to be non-specific and lacked immune memory recall responses. It is now appreciated that NK cell responses to viral infections can be specific and in some cases memory recall responses are established. Increasing evidence also illuminates the complexity of NK cell interactions with both innate and adaptive immune cells. Here, we summarize the evidence for NK cell-specific memory responses to viral infections and the intricate reciprocal interactions between NK cells and other immune cells that dictate their activation and effector functions.

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CCR2 Defines a Distinct Population of NK Cells and Mediates Their Migration during Influenza Virus Infection in Mice

Cited by 55 publications

References 39 publications

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

NK cells in host responses to viral infections

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