CD spectra of solid-state samples

Abstract

Solid‐state CD spectroscopy can provide valuable information on conformation, intermolecular interactions, including chirality induction, and enantioselective reactions which occur specifically in the solid state. The technique can, however, suffer from serious artifacts. Some examples of solid‐state CD are given and potential artifacts are discussed. Chirality 12:269–277, 2000.© 2000 Wiley‐Liss, Inc.

Experimental aspects of solid state circular dichroism

“…4,5 A previous review on solid-state CD had been published 10 years ago in this journal by Reiko Kuroda. 6 The same author gave further important contributions on this subject with other extended texts in different books edited from 2000 to 2008. [7][8][9] Revisiting today the same argument gives us an opportunity to present a few further developments, but at the same time it allows us to extend the interest originally focused on inorganic samples.…”

Quantum chemical CD calculations of dioncophylline A in the solid state

“…Furthermore, to measure solid-state CD spectra, great care is needed to avoid or/and eliminate the inevitably expected artifacts. 13,14,15 In this paper, we describe the first theoretical and experimental solid-state CD investigations on the well-known natural product dioncophylline A (1) 16,17,18,19 as a model compound, which consists of two substantially different chromophoric units, viz. a naphthalene part and an isoquinoline portion, linked through a rotationally flexible, but still configurationally stable biaryl axis.…”

Recrystallization of Enantiomers from Conglomerates

“…However, there are serious limitations to these techniques since the collection of an isolated particle can be difficult and also because the analysis of a single particle necessitates high detection levels. To be exhaustive, let us also mentioned that the detection of a conglomerate can also be performed via thermal analysis (the construction of the binary phase diagram by simple measurements of the melting temperatures of the enantiomers and that of their corresponding racemic mixture can be used to identify the nature of the sample (conglomerate or racemic compound) (Neau et al, 1993) or Solid state circular dichroïsm (SS-CD) and CD microscopy (Kuroda et al, 2000;Claborn et al, 2003). The construction of a ternary isotherm is also a reliable method especially when a conglomerate of solvated phases is suspected.…”