CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy

Abstract

Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-ĸB (NF-ĸB) have been independently associated with prostate cancer (PC) progression. We investigated the correlations between these two factors and their prognostic relevance in terms of biochemical (prostate-specific antigen, PSA) relapse after radical prostatectomy (RP) for localized PC. Patients and Methods: The immunohistochemical expression of CD10 and NF-ĸB in samples from 70 patients who underwent RP for localized PC was correlated with the preoperative PSA level, Gleason score, pathological stage and time to PSA failure. Results: CD10 expression was inversely associated with NF-ĸB expression (p < 0.001), stage (p = 0.03) and grade (p = 0.003), whereas NF-ĸB was directly related with stage (p = 0.006) and grade (p = 0.002). The median time to PSA failure was 56 months. CD10 and NF-ĸB were directly (p < 0.001) and inversely (p < 0.001) correlated with biochemical recurrence-free survival, respectively. CD10 expression (p = 0.022) and stage (p = 0.018) were independently associated with time to biochemical recurrence. Conclusion: Low CD10 expression is an adverse prognostic factor for biochemical relapse after RP in localized PC, which is also associated with high NF-ĸB expression. Decreased CD10 expression which would lead to increased neuropeptide signaling and NF-ĸB activity may be present in a subset of early PCs.

Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network

“…The pan-Canadian multi-centre cohort is an important addition to PC research to support the validation of potential biomarkers that have been reported from studies using small cohorts from single institutions. Previously, we and others have shown that overall p65 expression, or more specifically its nuclear frequency in PC, is associated with BCR in single institution cohorts [8–14,21–23]. Here, we identified a threshold of p65 nuclear expression in a multi-centre cohort of 250 PC patients and validated this prognostic biomarker in a second independent multi-centre cohort of 1,262 PC patients.…”

Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection

“…In line with these opposing effects, the prognostic significance of NEP expression may vary between different tumor types. For example, NEP expression is a favorable prognostic factor in hepatocellular carcinoma19 and diffuse large B cell lymphoma,9 whereas it predicts poor outcome in prostate cancer, renal carcinoma, breast cancer, and endocrine pancreas cancer 10,11,17. According to our data in the current study, NEP expression was dramatically upregulated in IHCC tissues compared with noncancerous liver tissues.…”

CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis

“…Stromal CD10 expression was reported to correlate with poor prognosis in pancreatic cancer [ 13 ], breast cancer [ 14 ], and gastric carcinoma [ 15 ]. Similarly, tumor expression of CD10 has been reported to promote tumor progression in colorectal cancer [ 16 ], prostate cancer [ 17 – 20 ], bladder cancer [ 21 ], and melanoma [ 3 ]. On the other hand, CD10 has also been reported to inhibit tumor progression in cervical carcinoma [ 22 ] and ovarian cancer [ 23 ].…”