CD124 on monocytes in grass‐pollen allergy

Grzela, Katarzyna; Grzela, Tomasz; Łazarczyk, Maciej; Chmielewska-Szewczyk, D.; Korczak-Kowalska, G; Jóźwiak, Jarosław

doi:10.1034/j.1398-9995.2001.056003254.x

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…The Lagunera region is a semi‐desert area characterized by climatological conditions that favour extradomiciliary contact with airborne allergens such as thickets and grass, and a high prevalence of allergic rhinitis has been reported . In our study, the results obtained confirm higher total counts of eosinophils in the peripheral blood of children with allergies , associated with a higher percentage of Th and B cells that express CD69 and a greater percentage of B cells that express CD23 (the low‐affinity receptor for IgE), without observed effects on the expression of the IL‐4 receptor (CD124). As is discussed below, the highest percentages of CD4 + T lymphocytes and IL‐4 producing CD4 + T lymphocytes observed in children without allergies suggests a previous history of exposure to Cryptosporidium , without disregarding the participation of other parasites.…”

Section: Discussionsupporting

confidence: 82%

“…The aim of this study was to investigate allergy‐related immune markers in children naturally infected with Cryptosporidium . To achieve this, we analysed the following characteristics in a population of children with and without allergies, in a setting of natural Cryptosporidium infection: the levels of total IgE; the total counts of eosinophils, segmented neutrophils and total lymphocytes; the percentage of T (CD3 + ), Th (CD4 + ) and B (CD19 + ) lymphocytes; the proportion of Th1 and Th2 CD4 + lymphocytes (IFN‐γ‐ and IL‐4‐producing cells, respectively); the expression of activation markers such as CD69, one of the earliest markers induced upon activation in T and B lymphocytes ; the low‐affinity receptor for IgE (CD23), with an important role in the regulation of IgE synthesis in allergic diseases ; and the interleukin‐4 receptor‐α on B cells (CD124), whose expression is increased in nasal and bronchial mucosal biopsies in allergic patients .…”

Section: Introductionmentioning

confidence: 99%

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Modulation of the immune response by infection with Cryptosporidium spp. in children with allergic diseases

Guangorena-Gómez

Maravilla-Domínguez

García‐Arenas

et al. 2016

Parasite Immunology

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It has been demonstrated that the allergic response can be ameliorated by the administration of pathogen derivatives that activate Toll-like receptors and induce a Th1-type immune response (IR). Cryptosporidium is a parasite that promotes an IR via Toll-like receptors and elicits the production of Th1-type cytokines, which limit cryptosporidiosis. The aim of this study was to investigate allergy-related immune markers in children naturally infected with Cryptosporidium. In a cross-sectional study, 49 children with or without clinical diagnosis of allergies, oocysts of Cryptosporidium spp. in the faeces were screened microscopically. We microscopically screened for leucocytes, examined T and B cells for allergy-related activation markers using flow cytometry and evaluated serum for total IgE using chemiluminescence. Children with allergies and Cryptosporidium in the faeces had significantly lower levels of total IgE, B cells, CD19(+) CD23(+) and CD19(+) CD124(+) cells as well as a greater percentage of interferon-gamma (IFN-γ(+) ) and IL-4(+) CD4(+) cells than children with allergies without Cryptosporidium. This is the first description of the modulation of the IR in children with allergic diseases in the setting of natural Cryptosporidium infection. Our findings suggest the involvement of CD4(+) cells producing IL-4 and IFN-γ in the IR to Cryptosporidium in naturally infected children.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Modulation of the immune response by infection with Cryptosporidium spp. in children with allergic diseases

Guangorena-Gómez

Maravilla-Domínguez

García‐Arenas

et al. 2016

Parasite Immunology

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“…Receptors for immune regulators 2019, Vol. 21,3 2019, Т. 21, № 3 ских образцов, было то, что высокая экспрессия хемокиновых рецепторов коррелирует с тяжестью онкологической патологии, увеличением риска развития рецидива, а также смерти.…”

Section: рецепторы к иммунорегуляторамunclassified

“…Receptors for immune regulators 2019, Vol. 21,3 2019, Т. 21, № 3 ка или раком молочной железы ухудшает течение заболевания и способствует прогрессированию болезни, в результате чего снижается общая выживаемость и выживаемость без прогрессирования заболевания у пациентов.…”

Section: рецепторы к иммунорегуляторамunclassified

Expression Density of Receptors for Immunoregulatory Mediators as a Modulatory Component of Biological Effects of Mediators Upon Cells (Part 2)

et al. 2019

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The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven byin vitroandin vivostudies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.

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Expression of interleukin 4 receptors in bronchial asthma patients who underwent specific immunotherapy

Kowal

Osada

Zukowski

et al. 2004

Annals of Allergy, Asthma & Immunology

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CD124 on monocytes in grass‐pollen allergy

Cited by 3 publications

References 4 publications

Modulation of the immune response by infection with Cryptosporidium spp. in children with allergic diseases

Modulation of the immune response by infection with Cryptosporidium spp. in children with allergic diseases

Expression Density of Receptors for Immunoregulatory Mediators as a Modulatory Component of Biological Effects of Mediators Upon Cells (Part 2)

Expression of interleukin 4 receptors in bronchial asthma patients who underwent specific immunotherapy

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