2021
DOI: 10.1177/1533033820980088
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CD155-Prognostic and Immunotherapeutic Implications Based on Multiple Analyses of Databases Across 33 Human Cancers

Abstract: Growing evidence has suggested that CD155 participates in the regulation of many biological processes ranging cell growth, invasion, and migration from regulation of immune responses in most malignances. However, the impact of prognostic value and CD115-related immune response on the survival in multiple cancers remains incompletely clear. In our study, we assessed the prognostic significance and immune-associated mechanism of CD155 based on data from multiple databases and methods, including UCSC Xena, Oncomi… Show more

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Cited by 6 publications
(5 citation statements)
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“…Notably, the expression of CD155 has been found to be elevated across many types of cancer. 2 Interestingly, the protein uses an alternative splicing mechanism, producing 4 isoforms, 2 being soluble (CD155b and CD155g) and 2 being transmembrane protein (CD155a and CD155d). 3 Human tissues also express soluble isoforms of CD155 (sCD155) that lack the transmembrane region.…”
Section: Cd155 Is a Potential Biomarker In Basal Cell Carcinomamentioning
confidence: 99%
“…Notably, the expression of CD155 has been found to be elevated across many types of cancer. 2 Interestingly, the protein uses an alternative splicing mechanism, producing 4 isoforms, 2 being soluble (CD155b and CD155g) and 2 being transmembrane protein (CD155a and CD155d). 3 Human tissues also express soluble isoforms of CD155 (sCD155) that lack the transmembrane region.…”
Section: Cd155 Is a Potential Biomarker In Basal Cell Carcinomamentioning
confidence: 99%
“…An association of increased CD155 expression with a poor prognosis has been noted in several malignant tumors [ 147 , 148 , 149 , 150 ]. In GC, an association of increased expression of CD155 with poor OS was observed [ 131 , 151 ].…”
Section: Immune Checkpoint Expression In Connection With Clinical Features and The Therapeutic Efficacy Of Their Inhibitionmentioning
confidence: 99%
“…In prostate cancer, high expression of PVR receptors (CD155 and CD112) has been reported in patients with resistant and castration-sensitive prostate cancer; for this reason, these receptors were proposed as potential targets in prostate cancer [ 22 , 23 ]. Furthermore, a correlation between elevated expression of TIGIT and high-risk recurrence after radical prostatectomy has been shown [ 24 ].…”
Section: Introductionmentioning
confidence: 99%