CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population

Rahman, Mohammad Imtiazur; Jahan, Iffat; Khalid, Mir M.; Jahan, Israt; Ahammad, Rijwan Uddin; Nahar, Shamsun; Islam, Zhahirul

doi:10.1016/j.jneuroim.2017.11.013

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…On the other hand no associations were reported between CD1A and CD1D and PMT caused by Mycobacterium malmoense (Jones et al, 2001) .Significant associations were found between CD1A *01/02 and protection against GBS in Abruzzo region (Italy) population (Caporale et al, 2006) and in a Chinese population (Liu et al, 2016). However, no associations between GBS and CD1 A polymorphism were detected in German (Kuijf et al, 2008), Bangladeshi (Rahman et al, 2018) and Peruvian (Jaramillo-Valverde et al, 2019) populations. Suggesting the potential effect of ethnicity in this discrepancy between populations.…”

Section: Discussionmentioning

confidence: 99%

Research Article Association of non-synonymous mutations in CD1A and CD1D genes with colorectal cancer in Saudi Arabia

Alomar¹,

Al-Tamimi²,

Almanaa³

et al. 2020

Genet. Mol. Res.

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Cluster of differentiation 1 (CD1) is antigenpresenting molecule involved in the presentation of lipid and glycolipid antigens to specific T cells and natural killer T cells. They exhibit a low rate of polymorphism compared to classical major histocompatibility complex presenting molecules. In this case control study, we examined a possible association of genetic polymorphism in CD1A and CD1D genes with colorectal cancer (CRC) in a Saudi population consisting of 120 patients with CRC and 118 matched controls. They were genotyped for the CD1A T/C 622 and CD1D A/T 354 polymorphisms using PCR-SSP. An apparent protective effect of the C allele, heterozygous TC and additive TC + CC genotypes against CRC was observed. These associations were found only in individuals >57 years. No association was observed between the CD1D A/T 354 polymorphism and CRC.

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Section: Discussionmentioning

confidence: 99%

Research Article Association of non-synonymous mutations in CD1A and CD1D genes with colorectal cancer in Saudi Arabia

Alomar¹,

Al-Tamimi²,

Almanaa³

et al. 2020

Genet. Mol. Res.

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“…In a study in Bangladesh by Rahman et al . in 2017[ 21 ] (case 200, control 200), there was no association of CD1A and CD1E SNP observed in GBS. Similar result was observed for CD1 gene polymorphism in GBS by a study from Peru by Jaramillo-Valverde et al .…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-α, CD1A and CD1E genetic polymorphisms in Guillain-Barré syndrome: A study from India

Verma

Chakraborty

Jain

et al. 2023

Ann Indian Acad Neurol

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Background: Guillain–Barré Syndrome (GBS) is an acute acquired autoimmune inflammatory disorder of peripheral nerves and roots. The pathogenesis is essentially an aberrant post-infectious immune response in a genetically susceptible host milieu. Single nucleotide polymorphisms (SNP) in genes encoding the inflammatory mediators like TNF-α, CD1A and CD1E can influence their expression and level and the susceptibility and clinical course of disease in GBS. Objective: We tried to study the susceptibility of single nucleotide polymorphisms of TNF-α and CD1 genes in Guillain–Barré Syndrome in Indian population and determine the association in terms of genotype, allele and haplotype distribution along with individual subtype, severity and clinical outcome. Methodology: In this case-control study, we investigated the single nucleotide polymorphism pattern in the promoter region of TNF-α (-308 G/A), TNF-α (-863C/A), CD1A and CD1E genes using real-time polymerase chain reaction in 75 GBS patients and analysed in comparison with 75 age and sex-matched healthy controls. Results: The findings revealed that the allelic distribution of TNF-α (-308 G/A) *A allele was associated with GBS ( P value 0.04, Odds Ratio 2.03, 95% Confidence Interval 1.01–4.07). There was no association found with genotype, haplotype combination and other allele distribution for GBS in the study. CD1A and CD1E SNPs did not reveal any susceptibility for GBS. The subtype analysis did not reveal any statistical significance, except for CD1A *G allele with AMAN subtype ( P value 0.026). The haplotypic combinations and mutant allele of TNF-α (-308 G/A), TNF-α (-863C/A), CD1A and CD1E were significantly associated with severe GBS in the study. However, there was no association of any SNP for mortality and survival of GBS in the study. Conclusion: TNF-α (-308 G/A)*A allele might confer genetic susceptibility for GBS in Indian population. CD1 genetic polymorphism could not be considered for susceptibility to GBS. TNF-α and CD1 genetic polymorphism did not affect mortality in GBS.

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“…Association of other genes such as CD1, FCGR2A, FCGR3A, and TLR4 is reported, but is still controversial. 132,134,135 A genome-wide association study (GWAS) showed no significant association. 136 GWAS and conventional candidate gene approach identified diseases association of the common variants whose minor allele frequency is normally more than 5%.…”

Section: Development Of Gbs Involves Genetic Factors and Precedentmentioning

confidence: 99%

“…However, TNF‐α gene polymorphisms are associated with various inflammatory diseases and therefore are not involved in disease‐specific pathophysiology of GBS. Association of other genes such as CD1 , FCGR2A , FCGR3A , and TLR4 is reported, but is still controversial 132,134,135 . A genome‐wide association study (GWAS) showed no significant association 136 .…”

Section: Role Of Siglec‐10 In B Cell Tolerance To Glycolipidsmentioning

confidence: 99%

Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*

Tsubata

2022

Immunological Reviews

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B lymphocytes recognize various macromolecules including proteins, nucleic acids (NAs), polysaccharides, and glycolipids, and produce antibodies specific to these molecules. Antibody responses to nonprotein antigens play important roles in both infection immunity and development of autoimmune diseases. Antibody production to capsular polysaccharides is the major effector mechanism of acquired immunity in host defense against bacteria possessing capsules such as pneumococcus and H. influenzae. 1 In contrast, antibodies to NAs and glycolipids play crucial roles in development of systemic lupus erythematosus and Guillain-Barré syndrome, 2,3 respectively. B cells stimulated with non-protein antigens require distinct signals from those with protein antigens for activation and antibody production. Activation of B cells stimulated with protein antigens requires T cell-derived co-stimulatory signals such as CD40L (CD154) through cell-cell interaction with T cells activated by the same antigens. 4-6 In contrast, polysaccharides such as dextran and pneumococcal capsular polysaccharides induce antibody response in mice that lack T cells, 7-9 although it is not yet clear how B cells are

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CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population

Cited by 8 publications

References 37 publications

Research Article Association of non-synonymous mutations in CD1A and CD1D genes with colorectal cancer in Saudi Arabia

Research Article Association of non-synonymous mutations in CD1A and CD1D genes with colorectal cancer in Saudi Arabia

Tumor necrosis factor-α, CD1A and CD1E genetic polymorphisms in Guillain-Barré syndrome: A study from India

Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens*

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