CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma

Abstract

CD20 has been reinvestigated in 66 patients with multiple myeloma (MM). Twelve of the patients (18%) expressed CD20, including 5 of 50 patients at diagnosis presenting 100% CD20 ؉ cells. Seven (58%) of 12 CD20 ؉ patients with MM had a small mature plasma cell morphology as opposed to 4 (7%) of 54 with CD20 ؊ MM (P ‫؍‬ .0001). Of note, 10 (83%) of 12 patients with CD20 ؉ MM had t(11;14) as opposed to 5 of 54 (9%) CD20 ؊ patients (P < .001). All the patients with 100% CD20 ؉ cells presented with t(11;14) and 4 of 5 with a small mature plasma cell morphology. Thus, 66% of the patients with t(11;14) expressed CD20, whereas only 4% of the 51 patients lacking such translocation expressed CD20 (P < .0001). In conclusion, CD20 expression is associated with small mature plasma cell morphology and with

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

“…In this context, t (11:14) has been shown to correlate with expression of CD20 (38). Consistent with this finding, we detected an association between overexpression of cyclin D1, but not cyclin D2 or D3, with t(11:14) by fluorescence in situ hybridization (Table 2) and strong CD20 expression on all cyclin D1-expressing multiple myeloma cells ( Fig.…”

Six color flow cytometry detects plasma cells expressing aberrant immunophenotype in bone marrow of healthy donors

“…The data about the expression of CD20 on PCs of healthy people is conflicting (15,16). We found that the proportion of CD20 expressing PCs was highly variable from case to case in HDs and MM patients.…”

t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma

“…Also, other common features have been reported in both MM subsets, that is, lower secreting capacity, CD20 expression and association with IgM isotype. [9][10][11] On the other hand, both immature morphology and t(4;14) correlated with some adverse prognostic factors, including high tumor mass and C13A, whatever the presence or absence of plasmablasts. In addition, higher serum level of sIL6-R, b 2 M and PC proliferative indices have been reported in both t(4;14) and plasmablastic MM subtypes.…”