CD200 is a new prognostic factor in multiple myeloma

Moreaux, Jérôme; Hose, Dirk; Rème, Thierry; Jourdan, Éric; Hundemer, Michael; Legouffe, Eric; Moine, Philippe; Bourin, Philippe; Moos, Marion; Corre, Jill; Möhler, Thomas; Vos, John De; Rossi, Jean François; Goldschmidt, Hartmut; Klein, Bernard

doi:10.1182/blood-2006-06-029355

Cited by 209 publications

(193 citation statements)

References 17 publications

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“…On dendritic epi-dermal T cells, CD200R crosslinking inhibited ␣CD3-induced proliferation and cytokine secretion (Rosenblum et al, 2005). Recent findings indicate that CD200 expression is up-regulated on leukaemias (Moreaux et al, 2006;Tonks et al, 2007;McWhirter et al, 2006). In addition, blockade of the interaction between CD200 on leukaemic B cells and CD200R on PBMC was found to inhibit tumour growth in an in vivo model of tumour rejection (Kretz-Rommel et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

Rijkers

Ruiter

Baridi

et al. 2008

Molecular Immunology

118

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To ensure an adequate response against pathogens and prevent unwanted self-reactivity, immune cells need to functionally express both activating and inhibitory receptors. CD200R is an inhibitory receptor mainly expressed on myeloid cells that down-modulates cellular activation both in vivo and in vitro. Although previously mainly studied as a regulator of myeloid function, we now show that CD200R is differentially expressed on human and mouse T-cell subsets. In both species, CD4 + T cells express higher amounts of CD200R than CD8 + T cells, and memory cells express higher amounts of CD200R than naïve or effector cells. CD200R expression is up-regulated on both CD4 + and CD8 + T cells after stimulation in vitro. Furthermore, we show CD200R expression on human and mouse B cells. In human tonsils, CD200R is differentially expressed on B cells, with high expression on memory cells and plasmablasts. Mice lacking the ligand for CD200R, CD200 −/− mice, do not show abnormal composition of the lymphocyte compartment and have normal B cell responses to antigenic challenge. Although the functional implications remain to be elucidated, the expression of CD200R on lymphocytes suggests a much broader role for CD200R-mediated immune regulation than previously anticipated.

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Section: Discussionmentioning

confidence: 99%

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

Rijkers

Ruiter

Baridi

et al. 2008

Molecular Immunology

118

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“…Expression of CD200 is an independent prognostic factor for multiple myeloma and acute myeloid leukemia, predicting reduced overall survival of these patients (Moreaux et al, 2006;Tonks et al, 2007). CD200 is the ligand for CD200 receptor (CD200R), which is an immune inhibitory receptor expressed on myeloid and lymphoid cells and is considered an important immunological checkpoint (Wright et al, 2001;Rijkers et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

CD200-CD200R signaling suppresses anti-tumor responses independently of CD200 expression on the tumor

et al. 2011

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“…2 It interacts with CD200R, a receptor expressed primarily on myeloid/monocyte lineage cells, and has a suppressive effect on T cell mediated immune response. 3,4 CD200 is expressed in a number of hematopoietic neoplasms, including acute myeloid leukemia, 5 multiple myeloma, 6 and is a marker of poor prognosis when expressed in these neoplasms, probably through its immunosuppressive effect on the host immune system.…”

mentioning

confidence: 99%

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

2012

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CD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in a number of B cell lymphoproliferative disorders, including primary mediastinal large B cell lymphoma, but not diffuse large B cell lymphoma, based on a preliminary study. Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma. CD200 exhibits the greatest staining sensitivity of the markers studied: 94%, compared with CD23 (69%), MAL (86%), TRAF (86%), and REL (77%). It exhibits staining specificity of 93%, similar to that of CD23 (93%) and MAL (97%), and greater than that of TRAF (77%) and REL (83%). We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma.

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CD200 is a new prognostic factor in multiple myeloma

Cited by 209 publications

References 17 publications

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

CD200-CD200R signaling suppresses anti-tumor responses independently of CD200 expression on the tumor

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers

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