CD203c is Overexpressed on Neoplastic Mast Cells in Systemic Mastocytosis and is Upregulated upon IgE Receptor Cross-Linking

Hauswirth, Alexander W.; Escribano, Luís; Prados, Aránzazu; Núñez, Rosa; Mirkina, Irina; Kneidinger, Michael; Florian, Stefan; Sonneck, Karoline; Vales, Anja; Schernthaner, Gerit‐Holger; Sánchez‐Muñoz, Laura; Sperr, Wolfgang R.; Bühring, Hans‐Jörg; Órfão, Alberto; Valent, Peter

doi:10.1177/039463200802100404

Cited by 46 publications

(48 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This protein defines the basophil lineage in the bone marrow and shows an elevated distribution on the cell surface of activated basophils. It can serve as a marker for the estimation of hypersensitivity to allergens [339][340][341][342]. Recent experiments implicate a dual role of NPP3 in vascular smooth muscle calcification by producing (together with NPP1) PP i from ATP on the one hand and subsequently hydrolyzing (together with TNAP) the PP i produced [7].…”

Section: General Properties and Functional Rolementioning

confidence: 99%

Cellular function and molecular structure of ecto-nucleotidases

Zimmermann

Zebisch

Sträter

2012

Purinergic Signalling

890

922

View full text Add to dashboard Cite

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate extracellular nucleosides for cellular reuptake and salvage via nucleoside transporters of the plasma membrane. The extracellular adenosine formed acts as an agonist of purinergic P1 receptors. They also can produce and hydrolyze extracellular inorganic pyrophosphate that is of major relevance in the control of bone mineralization. This review discusses and compares four major groups of ectonucleotidases: the ecto-nucleoside triphosphate diphosphohydrolases, ecto-5′-nucleotidase, ecto-nucleotide pyrophosphatase/phosphodiesterases, and alkaline phosphatases. Only recently and based on crystal structures, detailed information regarding the spatial structures and catalytic mechanisms has become available for members of these four ecto-nucleotidase families. This permits detailed predictions of their catalytic mechanisms and a comparison between the individual enzyme groups. The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.

show abstract

Section: General Properties and Functional Rolementioning

confidence: 99%

Cellular function and molecular structure of ecto-nucleotidases

Zimmermann

Zebisch

Sträter

2012

Purinergic Signalling

890

922

View full text Add to dashboard Cite

show abstract

“…Mouse bone marrow-derived mast cells (BMMCs) highly express CD39 and CD73 (Bulanova E., unpublished observation) and therefore might contribute to the concentration of ATP and its derivatives, ADP and AMP, in the microenvironment. Importantly, E-NPP3 (CD203c) was recently identified as a novel activation-linked surface marker on human mast cells and basophils [32]. It is upregulated in response to IgE crosslinking and highly expressed on neoplastic mast cells in patients with systemic mastocytosis [32].…”

Section: Mast Cellsmentioning

confidence: 99%

“…Importantly, E-NPP3 (CD203c) was recently identified as a novel activation-linked surface marker on human mast cells and basophils [32]. It is upregulated in response to IgE crosslinking and highly expressed on neoplastic mast cells in patients with systemic mastocytosis [32]. The expression and role of these and other ATP-hydrolyzing enzymes for the biology of mast cells remains to be elucidated.…”

Section: Mast Cellsmentioning

confidence: 99%

P2 receptor-mediated signaling in mast cell biology

Bulanova

Bulfone–Paus∥

2009

Purinergic Signalling

101

View full text Add to dashboard Cite

Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and antitumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.

show abstract

“…Опухолевые ТК, как правило, характеризуются аномальной экспрессией CD25, с или без CD2 [10,[32][33][34][35][36][37], CD123, CD203c, CD63, CD69 или CD45, а также низким уровнем экспрессии CyB12 [34,38]. ТК при СМЦ характеризуются аберрантной анти-генной экспрессией, что позволяет проводить четкую дифферен-циальную диагностику от нормальных ТК с чувствительностью выше 98% и специфичностью 100% [32].…”

Section: таблица в-и с-признаки мц (воз 2008)unclassified