2018
DOI: 10.1038/s41423-018-0028-9
|View full text |Cite
|
Sign up to set email alerts
|

CD26 – The emerging role of a costimulatory molecule in allograft rejection

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(5 citation statements)
references
References 10 publications
0
5
0
Order By: Relevance
“…Some studies have reported that CD26 provides a costimulatory signal and increases cytokine production in CD8 + T cells [28]. Given its costimulatory role, CD26 blockade attenuates organ transplantation [29,30] and skin allograft rejections in animal models [31,32]. Moreover, CD26 plays an essential role in the formation of memory CD8 + T cells in viral infections [33] but their frequency is reduced in HIV-infected individuals [34].…”
Section: Introductionmentioning
confidence: 99%
“…Some studies have reported that CD26 provides a costimulatory signal and increases cytokine production in CD8 + T cells [28]. Given its costimulatory role, CD26 blockade attenuates organ transplantation [29,30] and skin allograft rejections in animal models [31,32]. Moreover, CD26 plays an essential role in the formation of memory CD8 + T cells in viral infections [33] but their frequency is reduced in HIV-infected individuals [34].…”
Section: Introductionmentioning
confidence: 99%
“…It is still unknown how these two receptors are involved in the evolution of autoHSCT and the underlying disease in pediatric patients. CD26 is a dipeptidyl peptidase with a immunoregulatory role in many immune cell types 9799 , and some authors have found that high frequencies of transplanted CD26+ lymphocytes have a beneficial effect on NK cell recovery after autoHSCT in MM patients 100 . Conversely, others have shown that lower CD26 expression on different immune cell subtypes, including NK cells, of the donor stem cell harvest is associated with better survival in alloHSCT 101 .…”
Section: Discussionmentioning
confidence: 99%
“…The decrease of CXCR4 and CD26 surface expression seems to spare the T-cytotoxic and the NK lymphocytes. This observation is surprising since both molecules have documented biological roles on these cell types [ 11 , 35 , 37 39 ]. It could result from their lower basal expression levels, limiting our ability to distinguish small variations.…”
Section: Discussionmentioning
confidence: 99%
“…However, the validity of a similar paradoxical mechanism underlying HHT-related infection profile is not obvious, since WHIM syndrome is due to a CXCR4 gain-of-function mutation, resulting in prolonged retention of leukocytes in bone marrow and, consequently, panleukopenia, whereas no evidence of such behaviour is currently available for naive T-helper lymphocytes in HHT patients. Of note, the CD26 expression on T lymphocytes is regulated upon activation in inflammatory contexts such as rheumatoid arthritis or allograft rejection [ 11 , 42 ]. Therefore, inflammation could also participate in the shift of the CXCR4/26 ratio in HHT patients with a history of severe infection, despite the significant time elapsed between the last episode of infection and the time of enrollment.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation