CD34 as a marker for evaluating angiogenesis in cervical cancer

Evaluation of tumor angiogenesis in patients with non-small cell lung carcinoma

“…The vast majority of authors recommend that counting of neoangiogenesis vessels should be correlated to a surface area of 1 mm2 [14][15][16]. Currently, certain authors consider that one of the possible limitations of the importance of microvascular density in these patients is that immunohistochemistry is a semiquantitative method prone to subjective factors occurring during the course of evaluation of the patients [17].…”

New Biomarkers for Cervical Cancer – Perspectives from the IGF System

“…Other studies have proposed anti-CD34 as a marker for evaluating angiogenesis in cervical cancer (Vieira et al, 2004(Vieira et al, , 2005. Anti-CD34 antibody is a highly sensitive marker for endothelial cell differentiation and has also been studied as a marker for vascular tumours (Stross et al, 1989;Traweek et al, 1991).…”

“…Anti-CD34 antibody is a highly sensitive marker for endothelial cell differentiation and has also been studied as a marker for vascular tumours (Stross et al, 1989;Traweek et al, 1991). Vieira et al (Vieira et al, 2005) showed that this antibody was able to detect a number of microvessels on neoplasm of the uterine cervix better than anti-factor VIII. They suggested that anti-CD34 antibody reactivity in cervical carcinoma is associated with pathoanatomical features, as microvessel density or invasion, indicative of poorer prognosis and greater risk of recurrence (Vieira et al, 2005).…”

“…Vieira et al (Vieira et al, 2005) showed that this antibody was able to detect a number of microvessels on neoplasm of the uterine cervix better than anti-factor VIII. They suggested that anti-CD34 antibody reactivity in cervical carcinoma is associated with pathoanatomical features, as microvessel density or invasion, indicative of poorer prognosis and greater risk of recurrence (Vieira et al, 2005). Briefly, they showed lymphatic invasion in 40% of the cases, while vascular and perineural invasion was observed in 24% and 19% of the cases, in a population of 62 patients diagnosed with invasive cervical carcinoma, stages Ib and IIa.…”

Shadow Keyplayers of the Uterine Cervix Lesions Progression and Metastasis

“…Most of the papers concerning angiogenesis were based on description of growth factors and/or microvessel density assessed in cervical lesions, especially in invasive carcinomas.The cellular and molecular mechanisms of the angiogenic switch in preneoplastic lesions of the uterine cervix are still less studied. The assessment of angiogenesis in uterine cervix lesions was performed using pan-endothelial markers such as CD31, CD34 and von Willebrand factor, which are not specific enough to differentiate between endothelial cells from normal, activated or tumor vessels [3][4][5]. All these antibodies stain both normal and tumor vessels.…”