Cd34 Expression as a Surrogate Marker for Diagnosis of Invasive Ductal Carcinoma of Breast.

Abstract

Background : The normal stroma of breast has enormous numbers of CD34+ brocytes therefore loss of CD34 expression in mesenchymal cells has been considered as signicant in malignant transformation and as such thought to be conclusive proof in IDC. This hypothesis leads to the identication of a new marker to diagnose cases of IDC. This study is aimed to establish the role of CD34 in diagnosis of IDC of breast. AIM: To establish the CD34 stromal expression as signicant immunohistochemical marker and to establish its efcacy as diagnostic tool to diagnose IDC. Result: A total of 50 cases of already diagnosed invasive ductal carcinoma of breast were selected and CD34 staining was performed on parafn section of all specimens. Most of the patients were in age group 35-50 years who presented with breast lumps. 50 cases of invasive ductal carcinoma were seen with 22 cases shows Lymphovascular and perineural involvement and 26 cases showed nipple areola involvement and 38 showed axillary lymph node metastasis. On histological grading of 50 malignant cases 06 cases were grade - III, 26 cases were grade- II and 18 were grade - I. Normal breast tissue was taken as internal control which show diffuse CD34 expression in stroma while there is loss of expression of CD34 in stroma in inltrating ductal carcinoma. Thereby conrms the loss of cell molecules adhesive property and signal transduction. Conclusion: There is obvious absence of expression of CD34 in malignant breast lesions. Therefore in this study we conclude that CD34 has potential to be used as surrogate diagnostic marker and management of IDC.