CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Higashida, Haruhiro; Hashii, Minako; Tanaka, Yukië; Matsukawa, Shigeru; Higuchi, Yoshinori; Gabata, Ryosuke; Tsubomoto, Makoto; Seishima, Noriko; Teramachi, Mitsuyo; Kamijima, Taiki; Hattori, Tsuyoshi; Hori, Osamu; Tsuji, Chiharu; Cherepanov, Stanislav M.; Shabalova, Anna A.; Gerasimenko, Maria; Minami, Kazunori; Yokoyama, Shigeru; Munesue, Seiichi; Harashima, Ai; Yamamoto, Yasuhiko; Салмина, А. Б.; Lopatina, Olga

doi:10.3390/cells9010062

Cited by 49 publications

(36 citation statements)

References 99 publications

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“…At the same time, the physiological functions of CD38 in the brain have also been established. Thus, CD38 has been shown to play an important role in the secretion of oxytocin (OT) in the hypothalamus and in the regulation of social memory and social interactions ( Higashida et al, 2019 ). In addition, recently, our group, together with Japanese colleagues, showed that NR corrects social deficits, as well as anxious behavior in CD157 knockout mice.…”

Section: Calorie Restriction and Cognitive And Social Determinants Ofmentioning

confidence: 99%

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

et al. 2021

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Over the past decades, the human life span has dramatically increased, and therefore, a steady increase in diseases associated with age (such as Alzheimer’s disease and Parkinson’s disease) is expected. In these neurodegenerative diseases, there is a cognitive decline and memory loss, which accompany increased systemic inflammation, the inflamm-aging, and the insulin resistance. Despite numerous studies of age-related pathologies, data on the contribution of brain insulin resistance and innate immunity components to aging are insufficient. Recently, much research has been focused on the consequences of nutrients and adiposity- and nutrient-related signals in brain aging and cognitive decline. Moreover, given the role of metainflammation in neurodegeneration, lifestyle interventions such as calorie restriction may be an effective way to break the vicious cycle of metainflammation and have a role in social behavior. The various effects of calorie restriction on metainflammation, insulin resistance, and neurodegeneration have been described. Less attention has been paid to the social determinants of aging and the possible mechanism by which calorie restriction might influence social behavior. The purpose of this review is to discuss current knowledge in the interdisciplinary field of geroscience—immunosenescence, inflamm-aging, and metainflammation—which makes a significant contribution to aging. A substantial part of the review is devoted to frontiers in the brain insulin resistance in relation to neuroinflammation. In addition, we summarize new data on potential mechanisms of calorie restriction that influence as a lifestyle intervention on the social brain. This knowledge can be used to initiate successful aging and slow the onset of neurodegenerative diseases.

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Section: Calorie Restriction and Cognitive And Social Determinants Ofmentioning

confidence: 99%

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

et al. 2021

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“…However, aging effects in CD38 KO mice have been well studied [36,44], but these mice were produced on an ICR genetic background. Few reports are available regarding aging in the ICR strain [1,6,40]. In this respect, the current report is unique.…”

Section: Discussionmentioning

confidence: 94%

“…When cADPRsensitive CD38-dependent oxytocin release is disrupted, abnormal social behavior can be induced in mice with a null mutation in the Cd38 gene (CD38 KO mice). CD38 KO pups exhibited a higher level of locomotor activity and a lower number of ultrasonic vocalizations than wild type (WT) pups [1,8,9]. Young adult (approximately 8-12 weeks old) CD38 KO mice showed increased locomotory activity, de cits in social memory (amnesia), reductions in anxiety-like behavior, and impairment in parental behavior [6,10].…”

Section: Introductionmentioning

confidence: 99%

“…Immune-related CD38 and CD157 are similar molecules that share enzymatic functions [1][2][3][4]. Both molecules possess cyclase activity and can metabolize nicotinamide adenine dinucleotide (NAD) into ADP-ribose and cyclic ADP-ribose (cADPR), which are important second messengers that can potentially activate TRPM2 channels and trigger Ca 2+ mobilization in ryanodine receptor-sensitive Ca 2+ pools [1][2][3]5]. This increase in the intracellular free Ca 2+ concentration has been shown to facilitate oxytocin release into the brain and the systemic circulation at the posterior pituitary gland [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

Gerasimenko

Lopatina²,

Shabalova

et al. 2020

Preprint

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The ability of CD38 and CD157 to consume nicotinamide adenine dinucleotide (NAD) has received much attention because aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare the effects of age-associated changes on the general health and brain function impairment of Cd157 and Cd38 knockout (CD157 KO and CD38 KO) mice. Body weight and behaviors were measured in 8-week-old (young adult) or 12-month-old (middle-aged) male mice of both KO strains. The locomotor activity, anxiety-like behavior, and social behavior of mice were measured in open field, and three-chamber tests. Middle-aged CD157 KO male mice gained more body weight than young adult mice, while little or no body weight gain was observed in middle-aged CD38 KO mice. Middle-aged CD157 KO mice displayed increased anxiety-like behavior and decreased sociability and interaction compared with young adult KO mice. Middle-aged CD38 KO mice showed less anxiety and hyperactivity than CD157 KO mice, similar to young adult CD38 KO mice. The results reveal marked age-dependent changes in male CD157 KO mice but not in male CD38 KO mice. We discuss the distinct differences in aging effects from the perspective of inhibition of NAD metabolism in CD157 and CD38 KO mice, which may contribute to differential behavioral changes during aging.

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“…CD38 is a transmembrane glycoprotein with adenosine diphosphateribosyl-ribosyl cyclase activity, which plays an important role in the regulation of hormonal production as well as cell differentiation and migration [26]. CD38 is expressed in hematopoietic cells (B-and T-lymphocytes) and hypothalamic neurons.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study

Tereshchenko¹,

Каспаров²,

Zobova³

et al. 2020

Preprint

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Oxytocin (OT) is regarded as an extremely important prosocial neuropeptide that dramatically affects the establishment of social connections from infancy to adulthood. OT effects on the psychoemotional state are pretty individual and may be dependent on age, gender, ethnocultural factors, social environment, the presence of stress factors, and features of personality. The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathological screening tool and is recommended for the detection and classification of psychosocial problems in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18) explored the relation of SDQ scales in relation to genotypes of CD38 gene that controls oxytocin release, rs3796863, and oxytocin receptor gene (OXTR), rs53576. The results of our study show that during the adolescence period, OT pathway high activity can cause some negative effects, such as emotional instability in young (aged 12–14) adolescent girls in the case of carriage of the rs3796863 A allele and emotional disturbances in older (aged 15–18) adolescent boys who are carriers of a GG variant of rs53576. Our results support the hypothesis of OT-mediated excessive social sensitivity which can lead to some age-sex depending psychosocial problems during adolescence.

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CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cited by 49 publications

References 99 publications

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study

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