CD4+CD39+ cells in patients with hematologic malignancies

Nanava, Nino; Metreveli, Sophio; Giorgobiani, Giorgi; Chikovani, Tinatin; Janikashvili, Nona

doi:10.52340/gs.2022.04.05.03

Cited by 3 publications

(3 citation statements)

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“…It was discovered that MMP-2 levels were negatively associated with blood leucocyte count and complement C4 level. Blood leucocyte count is an inflammatory marker ( 19 ). The complement system is associated with different immune reactions, such as cell lysis and the inflammatory response ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Association of plasma MMP-2 levels and prognosis of patients with intracerebral hemorrhage: a prospective cohort study

Yu,

Peng,

Chen

et al. 2023

Front. Neurol.

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ObjectiveThe role of MMP-2 in patients with ICH is controversial and the impact of plasma MMP-2 level on clinical outcome is still unclear.Materials and methodsIn this study, the peripheral venous blood was acquired from 93 patients with ICH and 88 healthy controls within 24 h of hospitalization and at enrollment. We retrospectively investigated plasma MMP-2 levels of patients and healthy controls. The edema volume, the NIHSS score, the GCS score, and mRS were used to assess and quantify neurological deficit following ICH. Logistic regression analysis was configured to determine the independent relation of plasma MMP-2 levels with clinical outcomes. In addition, the plasma MMP-14 levels and complement C4 level were tested to explore the relationship with plasma MMP-2 level.ResultsThere was a significant reduction of plasma MMP-2 levels in ICH patients than that in healthy controls (38.02 ± 1.71 vs. 54.03 ± 2.15, p < 0.0001), and MMP-2 is negatively correlated with the edema volume (r = −0.2187, p < 0.05), NIHSS score (r = −0.2194, p < 0.05), blood leucocyte count (r = −0.2549, p = 0.012), and complement C4 level (r = −0.2723, p = 0.005). There is positive correlation between MMP-2 level and GCS score (r = 0.2451, p = 0.01) and MMP-14 level (r = 0.7013, p = 0.005). The multivariate analysis revealed that reduced plasma MMP-2 level is associated with elevated edema volume (OR = 0.2604, 95% CI [0.07 to 0.84], p = 0.02).ConclusionThe plasma MMP-2 level in patients with ICH is significantly lower than that of healthy controls, and plasma MMP-2 level may be a prognostic factor. Plasma MMP-2 levels are correlated with the clinical outcomes of patients and negatively correlated with blood leucocyte count and complement C4 level in patients with ICH.

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Section: Discussionmentioning

confidence: 99%

Association of plasma MMP-2 levels and prognosis of patients with intracerebral hemorrhage: a prospective cohort study

Yu,

Peng,

Chen

et al. 2023

Front. Neurol.

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“…Abnormal increases or decreases in cell counts may indicate an underlying biological process taking place, like inflammation or immune response. Also, values such as the Neutrophil-Lymphocyte ratio, Platelet-Monocyte ratio, or Platelet-Lymphocyte ratio are recognized as inflammatory markers [Nanava et al, 2020]. Table 7.2 shows analyte means and standard deviations, as well as the employed units of measure in each of our cohorts.…”

Section: Complete Blood Count and Datamentioning

confidence: 99%

Ensemble Learning through Rashomon Sets

Zuin,

Veloso

2024

Anais Do XXXVII Concurso De Teses E Dissertações (CTD 2024)

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Criar modelos a partir de observações e garantir sua eficácia em novos dados é a essencia do aprendizado de máquina. No entanto, selecionar modelos que generalizem bem para dados futuros continua sendo uma tarefa desafiadora. Neste trabalho, investigamos como os modelos se comportam em conjuntos de dados com funções de geração de dados distintas mas ainda correlacionadas. A motivação é estudar o Efeito Rashomon, que ocorre quando um problema admite a existência de vários modelos distintos com desempenho semelhante. Problemas do mundo real frequentemente exibem múltiplas estruturas locais nos dados, resultando em múltiplos modelos de alto desempenho sujeitos ao Efeito Rashomon. Propomos estratificar durante treino o espaço de soluções em grupos de modelos coerentes ou contrastantes. A partir desses grupos de Rashomon, contruimos um comitê onde cada constituinte cobre uma região distinta do espaço. Validamos nossa abordagem em conjuntos de dados abertos e reais. Nossa abordagem supera o estado-da-arte, melhorando a AUROC em até 0,20+ nos cenários onde a razão de Rashomon é alta.

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“…A CBC commonly includes red blood cells (RBCs), hemoglobin, hematocrit, RBC indices, such as RBC distribution width (RDW), white blood cells (WBCs) with differentials (i.e., neutrophils, lymphocytes, monocytes, eosinophils, and basophils), and platelets and platelet indices, including platelet distribution width (PDW) and mean platelet volume (MPV) [14,15]. Inflammation-related markers determined from a CBC include WBCs, neutrophils, monocytes, lymphocytes, MPV, PDW, and various ratios, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), plateletto-monocyte ratio (PMR), MPV-to-lymphocyte ratio (MPVLR), and MPV-to-platelet ratio (MPVPR) [16][17][18][19][20][21][22][23][24][25]. Despite an increasing number of studies evaluating CBC indices in ASD and ADHD children [26][27][28][29][30][31][32][33], findings regarding ASD and ADHD at adolescent age are scarce.…”

Section: Introductionmentioning

confidence: 99%

Peripheral Inflammatory Markers in Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder at Adolescent Age

Ferencova

Višňovcová

Ondrejka

et al. 2023

IJMS

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Autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) are associated with immune dysregulation. We aimed to estimate the pro- and anti-inflammatory activity/balance in ASD and ADHD patients at a little-studied adolescent age with respect to sex. We evaluated 20 ASD patients (5 girls, average age: 12.4 ± 1.9 y), 20 ADHD patients (5 girls, average age: 13.4 ± 1.8 y), and 20 age- and gender-matched controls (average age: 13.2 ± 1.9 y). The evaluated parameters included (1) white blood cells (WBCs), neutrophils, monocytes, lymphocytes, platelets, platelet distribution width (PDW), mean platelet volume, and derived ratios, as well as (2) cytokines—interferon-gamma, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10, tumor necrosis factor-alpha (TNF-α), and derived profiles and ratios. ASD adolescents showed higher levels of WBC, monocytes, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10, macrophages (M)1 profile, and anti-inflammatory profile than the controls, with ASD males showing higher monocytes, IL-6 and IL-10, anti-inflammatory profile, and a lower T-helper (Th)1/Th2+T-regulatory cell ratio than control males. The ADHD adolescents showed higher levels of PDW, IL-1β and IL-6, TNF-α, M1 profile, proinflammatory profile, and pro-/anti-inflammatory ratio than the controls, with ADHD females showing a higher TNF-α and pro-/anti-inflammatory ratio than the control females and ADHD males showing higher levels of IL-1β and IL-6, TNF-α, and M1 profile than the control males. Immune dysregulation appeared to be different for both neurodevelopmental disorders in adolescence.

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CD4+CD39+ cells in patients with hematologic malignancies

Cited by 3 publications

References 0 publications

Association of plasma MMP-2 levels and prognosis of patients with intracerebral hemorrhage: a prospective cohort study

Association of plasma MMP-2 levels and prognosis of patients with intracerebral hemorrhage: a prospective cohort study

Ensemble Learning through Rashomon Sets

Peripheral Inflammatory Markers in Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder at Adolescent Age

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