CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: An immunohistochemical variant of mycosis fungoides

Hodak, Emmilia; David, Michael; Maron, Lea; Aviram, A; Kaganovsky, Ella; Feinmesser, Meora

doi:10.1016/j.jaad.2006.01.020

Cited by 107 publications

(104 citation statements)

References 35 publications

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“…This observation provides further evidence that the CD8 1 or CD4 À CD8 À immunophenotype in early-stage MF in general does not have prognostic significance, as has already been indicated by previous studies. 1,34 In summary, on the basis of our experience and the scanty relevant literature, hyperpigmented MF appears to be another atypical clinical variant of cutaneous T-cell lymphoma with an indolent course. It has a predilection for darkcomplexioned individuals and is characterized histologically by prominent interface changes and immunohistologically by predominantly CD8 1 and, less often, a CD4 À CD8 À phenotype.…”

Section: Discussionmentioning

confidence: 76%

“…1,34,35 Support for the role of cytotoxic T cells in the development of hyperpigmentation in MF in such cases was provided by our earlier study showing that most of the CD4 À CD8 À MF cases are positive for T-cellerestricted intracellular antigen, a cytotoxic protein 34 as is known for CD81 MF cases. 1 In our 3 patients with other unusual coexistent MF variants, all lesions in each case had the same immunophenotype.…”

Section: Discussionmentioning

confidence: 87%

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Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Pavlovsky

Mimouni

Amitay‐Laish

et al. 2012

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 87%

Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Pavlovsky

Mimouni

Amitay‐Laish

et al. 2012

Journal of the American Academy of Dermatology

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“…8,9 Only a few cases diagnosed as MF or MF-like lymphoma with a g/d+ phenotype have been reported. [12][13][14] Guitart et al 8 in their series of 53 cases of CTCL with g/d+ phenotype identified obviously 6 such patients to whom they referred as "MF-like" CGD-TCL; the disease in these patients followed a more indolent course. In contrast, some experts classified similar cases of epidermotropic infiltrates of TCRg+ cells based on the clinical presentation with patches and plaques straightforward as MF, labeling them as "TCRg+ MF."…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Kempf¹,

Kazakov

Scheidegger

et al. 2014

The American Journal of Dermatopathology

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Cutaneous [gamma]/[delta]+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a [gamma]/[delta]+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a [gamma]/[delta]+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-tomedium-sized lymphocytes. These cases corroborate the view that expression of a g/d+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

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“…In contrast to circulating MF/SzS cells, which usually have a CD4+/CD82 immunophenotype, 34,36 up to 10% of MF cases in the skin have a CD42/CD82 double-negative immunophenotype. 45,58 Other immunophenotypic variants of MF, including CD8+/CD42, CD4+/CD56+/CD82, CD56+/CD42/CD82, and CD8+/ CD56+/CD42 cases, have also been described. [58][59][60][61][62][63][64][65][66][67][68] Although most MF cases are thought to arise from the CD4+/CD82 T-helper memory subset, 2 it is unclear whether MF variants that …”

Section: Discussionmentioning

confidence: 99%

Flow Cytometric Evaluation of Skin Biopsies for Mycosis Fungoides

Jokinen

Fromm

Argényi

et al. 2011

The American Journal of Dermatopathology

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Multicolor flow cytometry (FC) is indispensable for lymphoma diagnosis and classification, but its utility in evaluating skin biopsies for mycosis fungoides (MF) is not well established. We describe the largest series to date of skin biopsies evaluated by FC for MF (n = 33), and we compare the flow cytometric results with the histologic, molecular, and clinical findings. Abnormal T-cell populations were identified by FC in 14 of 18 patients (78%) having histologically confirmed MF and in no patient whose histology was negative or indeterminate for MF (n = 14). One patient had histologic, flow cytometric, and molecular findings compatible with MF, but this patient's clinical course was more suggestive of a drug eruption. Fourteen of 15 abnormal T-cell populations showed definitive aberrant expression of at least 2 surface antigens, including CD2 (47%), CD3 (67%), CD4, CD5 (87%), CD7, and CD45 (67%); most cases (67%) had light scatter properties suggesting increased cell size and/or cytoplasmic complexity. The high specificity of FC suggests that it will be a useful adjunct to routine histology in the evaluation of diagnostic skin biopsies for MF.

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CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: An immunohistochemical variant of mycosis fungoides

Cited by 107 publications

References 35 publications

Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Flow Cytometric Evaluation of Skin Biopsies for Mycosis Fungoides

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