CD4+CXCR4+ T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease

Wang, Kaiwen; Zhao, Jiangfeng; Chen, Zhiwei; Li, Ting; Tan, Xiaoming; Zheng, Yue; Gu, Liyang; Guo, Li; Sun, Fangfang; Wang, Haiting; Li, Jiajie; Wang, Xiaodong; Riemekasten, Gabriela; Ye, Shuang

doi:10.1093/rheumatology/key425

Cited by 13 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a Japanese study, Yasunori Enomoto et al showed that higher soluble CD163 levels were associated with worse prognosis and forced volume vital percentage of predicted value [39]. Additionally, the measurement of several serum biomarkers, including Krebs von den Lungen-6 antigen [40], CD4+CXCR4+ T cells [41], microRNA-200c [42], soluble CD206 [43], and progranulin [44], succeeded to predict short-term or long-term prognosis in patients with PM/DM-ILD. The fact that high DDR acted as an independent predictor of 1-year mortality in our study suggests that this easy-toobtain biomarker may be used to identify high-risk patients that require more intensive treatment.…”

Section: Discussionmentioning

confidence: 99%

AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

Zhu

Wang

et al. 2020

Arthritis Res Ther

View full text Add to dashboard Cite

Objective To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). Patients and methods This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose DRR on admission were tested at West China Hospital of Sichuan University during the period from January 1, 2008, to December 31, 2018. Cox regression models were used to estimate hazard ratios for mortality in four predefined DRR strata (≤ 0.91, 0.91–1.26, 1.26–1.73, and > 1.73), after adjusting for age, sex, DRR stratum, diagnosis, overlap syndrome, hemoglobin, platelet count, white blood cell count, the percentage of neutrophils, neutrophil/lymphocyte ratio, albumin, creatine kinase, uric acid/creatinine ratio, triglycerides, or low-density lipoprotein. Results Higher DRR (> 1.73) was an independent predictor of 1-year mortality in multivariate Cox regression analysis (hazard ratio 3.423, 95% CI 1.481–7.911, p = .004). Patients with higher DRR more often required the use of mechanical ventilation and readmission for acute exacerbation of PM/DM-ILD at 1-year follow-up. Conclusion Higher DRR on admission for PM/DM-ILD patients are associated with increased mortality, risk of mechanical ventilation, and hospitalization in 1-year follow-up. This low-cost, easy-to-obtain, rapidly measured biomarker may be useful in the identification of high-risk PM/DM-ILD patients that could benefit from intensive management.

show abstract

Section: Discussionmentioning

confidence: 99%

AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

Zhu

Wang

et al. 2020

Arthritis Res Ther

View full text Add to dashboard Cite

show abstract

“…As a highly progressive disease, MDA5 + DM-ILD remains to be a big challenge despite of recent treatment advances 4 , 14 . Several prognostic indicators of the disease had been reported involving respiratory physiology parameters, laboratory biomarkers, and radiology features 1 , 6 , 15 , 16 . The current study focused on patients’ baseline pulmonary HRCT and attempted to quantitatively assess the disease in the regard of predicting six-month mortality.…”

Section: Discussionmentioning

confidence: 99%

A novel CT scoring method predicts the prognosis of interstitial lung disease associated with anti-MDA5 positive dermatomyositis

Zhang

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a life-threatening disease. This study aimed to develop a novel pulmonary CT visual scoring method for assessing the prognosis of the disease, and an artificial intelligence (AI) algorithm-based analysis and an idiopathic pulmonary fibrosis (IPF)-based scoring were conducted as comparators. A retrospective cohort of hospitalized patients with MDA5+ DM-ILD was analyzed. Since most fatalities occur within the first half year of the disease course, the primary outcome was the six-month all-cause mortality since the time of admission. A ground glass opacity (GGO) and consolidation-weighted CT visual scoring model for MDA5+ DM-ILD, namely ‘MDA5 score’, was then developed with C-index values of 0.80 (95%CI 0.75–0.86) in the derivation dataset (n = 116) and 0.84 (95%CI 0.71–0.97) in the validation dataset (n = 57), respectively. While, the AI algorithm-based analysis, namely ‘AI score’, yielded C-index 0.78 (95%CI 0.72–0.84) for the derivation dataset and 0.77 (95%CI 0.64–0.90) for the validation dataset. These findings suggest that the newly derived ‘MDA5 score’ may serve as an applicable prognostic predictor for MDA5+ DM-ILD and facilitate further clinical trial design. The AI based CT quantitative analysis provided a promising solution for ILD evaluation.

show abstract

“…As a highly progressive disease, anti-MDA5 positive DM-ILD remains to be a big challenge despite of recent treatment advances (4,18). Several prognostic indicators of the disease had been reported involving respiratory physiology parameters, laboratory biomarkers, and radiology features (1,6,19). The current study focused on patients' baseline pulmonary HRCT and attempted to quantitatively assess the disease in the regard of predicting six-month mortality.…”

Section: Discussionmentioning

confidence: 99%

MDA5 score--A Novel Lung Computed Tomography Scoring Method for Anti-Melanoma Differentiation-associated Gene 5-positive Dermatomyositis

Zhang

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) is a life-threatening disease with a 6-month mortality as high as 50%. Evaluation of pulmonary high-resolution computed tomography (HRCT) is crucial in the prognostic prediction. This study aimed to develop a novel CT visual scoring method for anti-MDA5 positive DM-ILD.Methods: A prospective cohort of hospitalized patients with anti-MDA5 positive DM-ILD was analyzed, and was further divided into a derivation dataset and a validation dataset. The primary outcome was the six-month all-cause mortality since the time of admission. Three components of baseline pulmonary CT images, i.e., ground glass opacity (GGO), consolidation and fibrosis were semi-quantitatively calculated in different lung lobes. The multivariable COX proportional hazards model was used to identify independent prognostic risk factors and corresponding coefficients, based upon which a scoring model was constructed. In addition, an artificial intelligence (AI) algorithm-based analysis and an idiopathic pulmonary fibrosis (IPF)-based scoring were conducted as comparators. The prediction accuracy of different methods was measured and compared by Harrell concordance index (C-index). Results: Overall, 173 eligible patients were included. A novel GGO and consolidation-weighted CT visual scoring model for anti-MDA5 positive DM-ILD, namely ‘MDA5 score’, was developed with C-index values of 0.80 (95%CI 0.75-0.86) in the derivation dataset (n=116) and 0.84 (95%CI 0.71-0.97) in the validation dataset (n=57), respectively. While, the AI algorithm-based analysis, namely ‘AI score’, yielded C-index 0.78 (95%CI 0.72-0.84) for the derivation dataset and 0.77 (95%CI 0.64-0.90) for the validation dataset. ‘MDA5 score’ outperformed and IPF-based scoring (‘IPF score’) with respect to discrimination and clinical usefulness.Conclusions: The novel derived ‘MDA5 score’ may serve as an applicable prognostic predictor for anti-MDA5 positive DM-ILD and facilitate further clinical trial design. The AI based CT quantitative analysis from COVID-19 provided a promising solution for ILD evaluation.

show abstract

CD4+CXCR4+ T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease

Cited by 13 publications

References 0 publications

AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases

A novel CT scoring method predicts the prognosis of interstitial lung disease associated with anti-MDA5 positive dermatomyositis

MDA5 score--A Novel Lung Computed Tomography Scoring Method for Anti-Melanoma Differentiation-associated Gene 5-positive Dermatomyositis

Contact Info

Product

Resources

About