CD44 deficiency leads to decreased proinflammatory cytokine production in lung induced by PCV2 in mice

Fu, Qiang; Hou, Linbing; Xiao, Peipei; Guo, Chunhe; Chen, Yaosheng; Liu, Xiaohong

doi:10.1016/j.rvsc.2014.09.012

Cited by 10 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we infected mice with PCV2 and results showed that PCV2 infection could induce the similar pathological changes in mice as that in pigs, which performed as IL-10 production, splenic lymphocytes depletion, and pulmonary lymphocytes infiltration (Segalés, 2012). These results were confirmed by other studies that PCV2 infection leads to lymphoid depletion and suppression of CD4 + T cell and CD8 + T cell functions in BALB/c mice, and interstitial pneumonia in C57BL/6 mice (Kiupel et al, 2001; Fu et al, 2014; Wang et al, 2017). Using il10 −/− mice, we found that IL-10 deficiency partly prevents the depletion of splenic lymphocytes and promotes the infiltration of pulmonary lymphocytes.…”

Section: Discussionsupporting

confidence: 88%

Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Zhang

et al. 2019

Front. Microbiol.

View full text Add to dashboard Cite

Interleukin (IL)-10, as a key anti-inflammatory cytokine, increases during porcine circovirus type 2 (PCV2) infection, but the role of IL-10 in the process remains to be defined. In the present study, using an IL-10 deficient mice model, we found that IL-10 deficiency prevented the reduction of splenic lymphocytes (CD45+ cells) induced by PCV2 and promoted CD4+ and CD8+ T cell infiltration in lungs through inducting more T cell chemokines (CCL3, CXCL9, and CXCL10). Simultaneously, PCV2 infection induced a significant increase of pro-inflammatory cytokines and PCV2-specific antibodies in IL-10 deficient mice than in wild-type mice, resulting in a lower viral load in lung and a milder lung lesion in IL-10 deficient mice relative to wild-type mice. Moreover, the amounts of pulmonary CD4+ and CD8+ T cells were all inversely correlated with the lung lesions, as well as the viral load of PCV2. These results demonstrate that PCV2 infection employs IL-10 to block the transfer of T cells to the lungs of mice, and IL-10 attenuates the production of pro-inflammatory cytokines and PCV2-specific antibodies. The lack of T cell infiltration, pro-inflammatory cytokines, and PCV2-specific antibodies promote PCV2 replication, leading to a more severe lung lesion in mice.

show abstract

Section: Discussionsupporting

confidence: 88%

Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Zhang

et al. 2019

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…CD44 is a widely expressed class I transmembrane glycoprotein in immunological and inflammatory responses . Upon infection with PCV2, the CD44 mRNA level in the lung tissue was upregulated, while CD44 deficiency resulted in decreased proinflammatory cytokine production in lungs of the PCV2‐infected mice, suggesting that CD44 plays a role in the development of the pneumonia response to PCV2 infection …”

Section: Immunology Of Pcv2 In Micementioning

confidence: 99%

“…These results further confirmed that HMGCR is negatively associated with PCV2 infection . Furthermore, CD44 has been reported to play an antiviral role in response to PCV2 infection . Astragalus polysaccharide (APS) treatments can reduce the pathological injury of tissues, inhibit PCV2 infection and decrease glucose‐regulated protein 78 and GADD153/CHOP gene mRNA and protein expression significantly by inhibiting endoplasmic reticulum stress .…”

Section: Evaluating Protective Chemicals and Antiviral Agents In Micementioning

confidence: 99%

Mouse models of porcine circovirus 2 infection

Ouyang

Liu

Ouyang

et al. 2018

Anim Models and Exp Med

View full text Add to dashboard Cite

PCV 2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases ( PCVD / PCVAD ). However, the exact mechanism underlying PCVD / PCVAD is currently unknown. Mouse models of PCV 2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV 2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV 2 studies.

show abstract

“…Furthermore, mouse models can be used to evaluate protective chemicals or antiviral agents. CD44 was reported to play an antiviral role in response to PCV2 infection [23]. Dietary supplementation with aluminosilicate [117], selenium yeast [118], arginine [119], proline [120], and L-glutamine [121,122] can enhance the immune system and confer mice with antiviral protection against PCV2.…”

Section: Mouse Model For Pcv2 Infectionmentioning

confidence: 99%

“…These cellular signal alterations include signals involved in the proliferation of PCV2, the initiation of apoptosis and autophagy, and the induction of the antiviral response [16][17][18][19][20][21]. Consequently, many proteins that are associated with cellular signaling pathways have been investigated as possible targets for antiviral strategies [16,17,[22][23][24][25][26][27][28][29]. The purpose of this review is to discuss the current state of knowledge on interactions between host cell factors and PCV2 and cell signaling in PCV2 infection and to provide veterinarians, diagnosticians, and veterinary virologists with a better knowledge of PCV2 infection.…”

Section: Introductionmentioning

confidence: 99%

Interactions of porcine circovirus 2 with its hosts

2016

View full text Add to dashboard Cite

Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine-producing countries. Since the discovery of this virus, considerable efforts have been devoted to understanding this pathogen and its interactions with its host. Here, we review the current state of knowledge on interactions between host cell factors and PCV2 with respect to viral proliferation, virus-induced cell apoptosis and autophagy, and host antiviral defenses during PCV2 infection. We also review mouse model systems for PCV2 infection.

show abstract

CD44 deficiency leads to decreased proinflammatory cytokine production in lung induced by PCV2 in mice

Cited by 10 publications

References 44 publications

Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Interleukin-10 Promotes Porcine Circovirus Type 2 Persistent Infection in Mice and Aggravates the Tissue Lesions by Suppression of T Cell Infiltration

Mouse models of porcine circovirus 2 infection

Interactions of porcine circovirus 2 with its hosts

Contact Info

Product

Resources

About