CD44 Gene Polymorphisms as a Risk Factor for Susceptibility and Their Effect on the Clinicopathological Characteristics of Lung Adenocarcinoma in Male Patients

Abstract

Lung adenocarcinoma is a subtype of lung cancer with high morbidity and mortality. CD44 is instrumental in many physiological and tumor pathological processes. The expression of unique single nucleotide polymorphisms (SNPs) contributes to protein dysfunction and influences cancer susceptibility. In the current study, we investigated the relationship between CD44 polymorphisms and the susceptibility to lung adenocarcinoma with or without epidermal growth factor receptor (EGFR) gene mutations. This study included 279 patients with lung adenocarcinoma. In total, six CD44 SNPs (rs1425802, rs11821102, rs10836347, rs13347, rs187115, and rs713330) were genotyped using a real-time polymerase chain reaction. We found no significant differences in genotype distribution of CD44 polymorphisms between EGFR wild-type and EGFR mutation type in patients with lung adenocarcinoma. We observed a strong association between CD44 rs11821102 G/A polymorphism and EGFR L858R mutation (odds ratio (OR) = 3.846, 95% confidence interval (CI) = 1.018–14.538; p = 0.037) compared with the EGFR wild-type group. In the subgroup of male patients with lung adenocarcinoma harboring the EGFR wild-type, both CD44 rs713330 T/C (OR = 4.317, 95% CI = 1.029–18.115; p = 0.035) and rs10836347 C/T polymorphisms (OR = 9.391, 95% CI = 1.061–83.136; p = 0.019) exhibited significant associations with tumor size and invasion. Data from the present study suggest that CD44 SNPs may help to predict cancer susceptibility and tumor growth in male patients with lung adenocarcinoma.

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

“…Liu et al (77) genotyped the CD44 gene in DNA extracted from blood lymphocytes of patients with NSCLC and found that the rs187115 (AG+GG) genotype was a significant predictor of bone metastasis and poor survival. It is widely accepted that the detection of single nucleotide polymorphisms in CD44 and other genes would be helpful in assessing the invasion ability of tumors (78).…”

Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells

“…CD44 molecule is expressed on HSC and regulatory T lymphocytes [4,11]. CD44 on HSC is a ligand for E-and L-selectins that maintain subpopulation of bone marrow stem cells [2,9,11]. CD44 is a receptor for hyaluronic acid [11] one of the main components of stem cell microenvironment.…”

Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients

“…Six CD44 genetic variants were checked based on the data of International HapMap Project and previous investigations 16 , 20 . Jiang et al revealed that the CD44 single nucleotide polymorphism (SNP) rs1425802 locates in the promoter region.…”