CD44 Variant 6 Expression and Tumor Budding in the Medullary Invasion Front of Mandibular Gingival Squamous Cell Carcinoma Are Predictive Factors for Cervical Lymph Node Metastasis

Okuyama, Kazuaki; Fukushima, Hiromasa; Naruse, Tomofumi; Yanamoto, Souichi; Tsuchihashi, Hiroki; Umeda, Masahiro

doi:10.1007/s12253-018-0529-y

Cited by 15 publications

(14 citation statements)

References 27 publications

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“…In the present study, 42.1% of cases which include mostly poorly differentiated and moderately differentiated OSCCs, show strong to intermediate staining, similar to the studies by Juneja s et al [15] , Rahmani et al [16] , Arya et al [17] where these variants showed strong to intermediate staining but constituted a minority of the total cases.…”

Section: Discussionsupporting

confidence: 91%

study of the expression of CD44 and Bcl-2 in oral squamous cell carcinoma and it’s correlation with histological grading

Miya

John

Vandana

et al. 2022

ijhs

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Introduction :Oral squamous cell carcinoma is one of the most prevalent cancers worldwide, with a global incidence of around 3,54,864 new cases and 1,77,384 deaths every year.Aim :To demonstrate and assess the prognostic significance of the expression of CD44 and Bcl-2 in squamous cell carcinomas of oral cavity by it’s correlation with the histological grade of the tumour.Methodology :This is a hospital based prospective study done over a period of 3 years at Kakatiya Medical College/MGM Hospital, Warangal, Telangana and includes 76 cases diagnosed as OSCC. Immunohistochemistry was done with markers CD44 and BCL2. ResultS:61.9% of WDSCC cases showed weak expression of CD44, 56.3% of MD SCC cases showed moderate expression, 50% of PD SCC cases showed strong expression and 50% showed moderate expression. 71.5% of WD SCC cases showed weak expression of BCL2, 46.9% of MD SCC cases showed moderate expression, 50% of PD SCC cases showed strong expression and 50% showed moderate expression. Conclusion: The present study, has showed that there is significant correlation between the histopathological grade of OSCC and the overexpression of CD44 and Bcl-2.

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Section: Discussionsupporting

confidence: 91%

study of the expression of CD44 and Bcl-2 in oral squamous cell carcinoma and it’s correlation with histological grading

Miya

John

Vandana

et al. 2022

ijhs

View full text Add to dashboard Cite

show abstract

“…For instance, CD44v6 promotes the colonization, invasion and metastasis of colorectal CSCs [118]. In addition, CD44v6 expression in the medullary invasion front of mandibular-invasive OSCC was significantly higher in the group with cervical lymph node metastasis, in comparison to tumor tissues without lymph node metastasis [119], which suggested that CD44v6 facilitated lymph node metastasis of this tumor type. Similar phenomena have also been observed in other tumor types, including glioblastoma [111], HNSCC [23], osteosarcoma [48], ovarian cancer [120], ESCC [100], and gastric cancer [121].…”

Section: Cd44 and Tumor Developmentmentioning

confidence: 90%

CD44 as a tumor biomarker and therapeutic target

et al. 2020

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CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple physiological processes, and aberrant expression and dysregulation of CD44 contribute to tumor initiation and progression. CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is involved in the regulation of diverse vital signaling pathways that modulate cancer proliferation, invasion, metastasis and therapy-resistance, and it is also modulated by a variety of molecules in cancer cells. In addition, CD44 can serve as an adverse prognostic marker among cancer population. The pleiotropic roles of CD44 in carcinoma potentially offering new molecular target for therapeutic intervention. Preclinical and clinical trials for evaluating the pharmacokinetics, efficacy and drug-related toxicity of CD44 monoclonal antibody have been carried out among tumors with CD44 expression. In this review, we focus on current data relevant to CD44, and outline CD44 structure, the regulation of CD44, functional properties of CD44 in carcinogenesis and cancer progression as well as the potential CD44-targeting therapy for cancer management.

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“…There are numerous reports that the expression of CD44v6 is an effective progression and prognosis marker in many cancers. For instance, CD44v6 is overexpressed in the mandibular invasive front of oral squamous carcinoma cells in patients with positive cervical lymph node metastasis and additionally, it is linked to the formation of tumour buds [ 43 ]. Yanamoto et al [ 45 ] reported that a high intensity of CD44v6 in tongue squamous cell carcinoma was associated with local recurrence.…”

Section: Cd44s Vs Cd44v: Roles and Functions In Cancer Progressionmentioning

confidence: 99%

CD44: A Multifunctional Mediator of Cancer Progression

et al. 2021

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CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and radiotherapy. The CD44 gene regularly undergoes alternative splicing, resulting in the standard (CD44s) and variant (CD44v) isoforms. The interaction of such isoforms with ligands, particularly hyaluronic acid (HA), osteopontin (OPN) and matrix metalloproteinases (MMPs), drive numerous cancer-associated signalling. However, there are contradictory results regarding whether high or low CD44 expression is associated with worsening clinicopathological features, such as a higher tumour histological grade, advanced tumour stage and poorer survival rates. Nonetheless, high CD44 expression significantly contributes to enhanced tumourigenic mechanisms, such as cell proliferation, metastasis, invasion, migration and stemness; hence, CD44 is an important clinical target. This review summarises current research regarding the different CD44 isoform structures and their roles and functions in supporting tumourigenesis and discusses CD44 expression regulation, CD44-signalling pathways and interactions involved in cancer development. The clinical significance and prognostic value of CD44 and the potential of CD44 as a therapeutic target in cancer are also addressed.

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CD44 Variant 6 Expression and Tumor Budding in the Medullary Invasion Front of Mandibular Gingival Squamous Cell Carcinoma Are Predictive Factors for Cervical Lymph Node Metastasis

Cited by 15 publications

References 27 publications

study of the expression of CD44 and Bcl-2 in oral squamous cell carcinoma and it’s correlation with histological grading

study of the expression of CD44 and Bcl-2 in oral squamous cell carcinoma and it’s correlation with histological grading

CD44 as a tumor biomarker and therapeutic target

CD44: A Multifunctional Mediator of Cancer Progression

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