2005
DOI: 10.1074/jbc.m506579200
|View full text |Cite
|
Sign up to set email alerts
|

CD46 Plays a Key Role in Tailoring Innate Immune Recognition of Apoptotic and Necrotic Cells

Abstract: Complement is the canonical innate immune system involved in host defense and tissue repair with the clearance of cell debris. In contrast to the robust armory mounted against microbial nonselfpathogens, complement is selectively activated on altered self (i.e. apoptotic and necrotic cells) to instruct the safe demise by poorly characterized mechanisms. Our data shed new light on the role of complement C1q in sensing nucleic acids (NA) rapidly exposed on apoptotic Jurkat T cell membranes and in driving C3 opso… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

7
110
0

Year Published

2008
2008
2015
2015

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 132 publications
(117 citation statements)
references
References 67 publications
7
110
0
Order By: Relevance
“…2C), skews nTregs and Tconv to Tr1 secreting IL-10, which prematurely imbalances the adaptive immunity toward immune suppression. The role of C3b protein, the CD46 agonist resulting from C′ activation, in the pathogenesis of active lupus patients is also suggested by the presence in the serum of these patients of soluble CD46 (30), product of proteolytic cleavage of apoptotic cell membranes (31). As for IFN-α, by reducing nTreg and Tconv number and function, this cytokine may further enhance the risk of autoimmunity and infection.…”
Section: Discussionmentioning
confidence: 99%
“…2C), skews nTregs and Tconv to Tr1 secreting IL-10, which prematurely imbalances the adaptive immunity toward immune suppression. The role of C3b protein, the CD46 agonist resulting from C′ activation, in the pathogenesis of active lupus patients is also suggested by the presence in the serum of these patients of soluble CD46 (30), product of proteolytic cleavage of apoptotic cell membranes (31). As for IFN-α, by reducing nTreg and Tconv number and function, this cytokine may further enhance the risk of autoimmunity and infection.…”
Section: Discussionmentioning
confidence: 99%
“…and Histones-DNA has been previously suggested to act as a C1q ligand on apoptotic cells (8). To further investigate the relevance of this interaction, surface plasmon resonance was used to analyze the binding affinity between C1q and DNA (Fig.…”
Section: C1q Binds To Late Apoptotic Cells and Interacts With Dnamentioning
confidence: 99%
“…The aim of the current study was to investigate new ligands for C1q on the surface of apoptotic cells. So far the only widely accepted C1q ligand on dying cells is DNA, which becomes accessible already very early on apoptotic cells, even before phosphatidylserine (PS) 3 (8). However, the precise region of C1q involved in DNA binding is a matter of controversy, because both the collagen-like stalk region and the globular head region have been implicated (7, 9 -12).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Second, the alternative pathway can be initiated by nucleophilic attack of C3 directly on the surface of allergen or by Factor B (Taube et al, 2006). Third, the recognition of PAMPs and danger-associated molecular patterns (DAMPs), such as nucleic acids on apoptotic cells (Elward et al, 2005) or allergen polysaccharide, (Bito, 1977, Zimmermann et al, 1989 can activate the lectin pathway. Fourth, proteases released from inflammatory cells or direct protease activity of allergens (Maruo et al, 1997) can drive the generation of C3a and C5a.…”
Section: Allergic Inflammation: Allergic Asthmamentioning
confidence: 99%