2012
DOI: 10.1016/j.canlet.2011.12.031
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CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes

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Cited by 48 publications
(34 citation statements)
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“…Instead we found CD49f to be upregulated. Combining cytokeratin staining with CD49f in the CellSearch System resulted in improved recovery of cell lines with EMT features (21). The value of CD49f on the recovery of MCAMpositive CTCs and the clinical value thereof will be subject in a future study.…”
Section: Discussionmentioning
confidence: 96%
“…Instead we found CD49f to be upregulated. Combining cytokeratin staining with CD49f in the CellSearch System resulted in improved recovery of cell lines with EMT features (21). The value of CD49f on the recovery of MCAMpositive CTCs and the clinical value thereof will be subject in a future study.…”
Section: Discussionmentioning
confidence: 96%
“…At the same time, it was discovered that epithelial tumors are characterized by a complex aneuploidy, which is inherited by the dissolved, circulating tumor cells, which therefore do not express CD45 or cytokeratins, but can be detected based on this chromosome rearrangement [67]. Another approach is to use CD146 to detect EpCAM-negative tumor cells and CD49f for the detection of CK-negative cells, improving detection rates [68]. The CTCscope method, which was published in 2012, is based on an RNA-ISH detecting epithelial as well as EMT-markers from blood samples.…”
Section: New Ctc-detection Strategiesmentioning
confidence: 99%
“…15 indicates a parallel relationship between EPCAM and ITGA6 proteins and link both proteins to breast cancer [32,33] (See Figure 6 in [13]). On the other hand, BCAM protein is up-regulated in colon cancer and promotes malignant transformation and/or metastasis [34].…”
Section: Accepted Manuscriptmentioning
confidence: 99%