CD5 positive B‐ALL, a uniquely aggressive subcategory of B‐ALL? A case report and brief review of the literature

Staley, Elizabeth M.; Feldman, Alexander; Koenig, Richard Gabriel; Hill, Benjamin C.

doi:10.1002/pbc.27484

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Many questions remain as to how Lin28b achieves enhanced B cell positive selection including to what extent death by neglect and negative selection is suppressed and how Lin28b deploys let-7 dependent versus independent mechanisms. Importantly, Lin28b(66) and CD5 (67) positive subtypes of pediatric acute lymphoblastic leukemias have been independently described and highlight the need to dissect whether or not endogenous Lin28b is complicit with c-Myc in the oncogenesis of B cell cancers.Previously, the topic of B-1 cell selection has mainly been studied through the narrow lens of a small number of germline encoded BCR specificities using BCR transgenic mice. Here, we use several innovative approaches to tackle this question in BCR WT mice.…”

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confidence: 99%

Lin28b controls a neonatal to adult switch in B cell positive selection

et al. 2019

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The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5+ immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19−/− adult mice. Thus, the temporally restricted expression of Lin28b relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.

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Lin28b controls a neonatal to adult switch in B cell positive selection

et al. 2019

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“…Of these patients, 38% were pediatric, 46% were AYA and only 15% were adults. 3 , 18 , 19 , 20 , 21 , 22 Among the 12 patients for whom cytogenetic data were available, 50% had high-risk cytogenetics in the form of complex karyotype (n = 4), BCR-ABL1 fusion (n = 1) and hypo-diploidy (n = 1). Though 83% (10 of 12) of these patients had disease remission at the end of induction, the follow-up data available for 6 patients showed disease relapse in all.…”

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confidence: 99%